Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children
Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children
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DOI：
10.1017/s000711451700366x
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发表时间：
2018-03-28
影响因子：
3.6
通讯作者：
Zimmermann, Michael B.
中科院分区：
文献类型：
--
作者：
Chimhashu, Tsitsi;Malan, Linda;Zimmermann, Michael B.
锌状态可能会影响脂肪酸（FA）代谢，因为它作为一个辅因子在FA去饱和酶和延长酶。锌补充影响锌缺乏大鼠的FA去饱和酶，但这是否发生在人类尚不清楚。我们评估了基线血浆锌（PZn）浓度和血浆总磷脂FA组成之间的关联，以及每日摄入锌强化水对贝宁儿童FA状态的影响。在186名学龄儿童中进行了为期20周的双盲随机对照试验。这些儿童被随机分配接受每日一部分的锌强化过滤水，平均每天提供2.8 mg锌或非强化过滤水。血浆总磷脂脂肪酸组成测定使用毛细管GLC和铅锌浓度的原子吸收光谱法。基线时，PZn与二高-亚麻酸（DGLA，r 0.182; P=0.024）和DGLA：亚油酸（LA）比值（r 0.293; P
Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children. The children were randomly assigned to receive a daily portion of Zn-fortified, filtered water delivering on average 2.8 mg Zn/d or non-fortified filtered water. Plasma total phospholipid FA composition was determined using capillary GLC and PZn concentrations by atomic absorption spectrometry. At baseline, PZn correlated positively with dihomo--linolenic acid (DGLA, r 0.182; P=0.024) and the DGLA:linoleic acid (LA) ratio (r 0.293; P