ISOLATION AND CHARACTERIZATION OF I5B2, A NEW PHOSPHORUS CONTAINING INHIBITOR OF ANGIOTENSIN-I CONVERTING ENZYME PRODUCED BY ACTINOMADURA SP
ISOLATION AND CHARACTERIZATION OF I5B2, A NEW PHOSPHORUS CONTAINING INHIBITOR OF ANGIOTENSIN-I CONVERTING ENZYME PRODUCED BY ACTINOMADURA SP
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DOI：
10.7164/antibiotics.37.965
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
SHIBA, T
中科院分区：
文献类型：
--
作者：
KIDO, Y;HAMAKADO, T;SHIBA, T
从马杜拉放线菌（Actinomadura sp.No.937ZE-1）的培养液中分离到一种新的血管紧张素I转换酶抑制剂15 B2。该化合物含有N-甲基缬氨酸、酪氨酸和1-氨基-2-（4-羟基苯基）乙基膦酸。该微生物还产生另一种抑制剂I5 B1，其与作为抗高血压剂从马杜拉放线菌分离的K-4相同。
A new inhibitor of angiotensin I converting enzyme, 15B2, was isolated from the culture broth of Actinomadura sp. No. 937ZE-1. This compound contains N-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. The microorganism also produced another inhibitor, I5B1, which is identical with K-4 isolated from Actinomadura sp. as an antihypertensive agent.