Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil
Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil
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DOI：
10.1161/01.str.28.1.124
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发表时间：
1997-01-01
期刊：
影响因子：
8.3
通讯作者：
Lassen, NA
中科院分区：
文献类型：
--
作者：
Nakagawara, J;Sperling, B;Lassen, NA
Background and Purpose [I-123]Iomazenil is a specific radioligand for the central benzodiazepine receptor that may be useful as an indicator of the intactness of cortical neurons after focal cerebral ischemia. We evaluated the binding of this receptor in reperfused cortex among patients with ischemic stroke to detect viable neurons in cortex that appeared structurally intact on conventional neuroimaging studies.Methods Fourteen patients were selected by (1) angiography within 24 hours of onset showing embolic occlusion of an intracranial artery, (2) cerebral blood flow showing ischemia of moderate severity in 12 cases and spontaneous reflow in 2 cases, and (3) thrombolysis with reperfusion within 24 hours in most cases. Thirty reperfused cortical areas that remained structurally intact, 7 infarcted cortical areas, and 6 contralateral cerebellar areas with reduced blood flow were selected as regions of interest to estimate receptor binding 5 days to 23 months after the stroke. A two-compartment model was used to compute the distribution volume (Vd) of iomazenil in relative units, with Vd proportional to benzodiazepine receptor concentration. The side-to-side asymmetry ratio of Vd was calculated.Results The mean asymmetry ratio was 0.89+/-0.11 (range, 0.64 to 1.05), 0.50+/-0.15 (range, 0.23 to 0.67), and 0.97+/-0.05 (range, 0.90 to 1.04) in reperfused cortex, infarcted cortex, and contralateral cerebellum, respectively. Compared with unity, both reperfused cortex and infarcted cortex showed significant decrease of Vd (P
