Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification
Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification
复制标题
DOI：
10.3109/s10165-005-0436-4
复制
发表时间：
2005-12
影响因子：
2.2
通讯作者：
F. Kugimiya;H. Chikuda;Satoru Kamekura;T. Ikeda;K. Hoshi;T. Ogasawara;Kozo Nakamura;U. Chung;H. Kawaguchi
中科院分区：
文献类型：
--
作者：
F. Kugimiya;H. Chikuda;Satoru Kamekura;T. Ikeda;K. Hoshi;T. Ogasawara;Kozo Nakamura;U. Chung;H. Kawaguchi
在脊椎动物骨骼发育过程中，附件骨骼是通过软骨内成骨形成的，这涉及到间充质细胞复杂的多步分化过程。在这个过程中，间充质凝聚最初分化为软骨细胞。然后中央的软骨细胞进一步分化为肥大的软骨细胞。肥大的软骨细胞表达多种成骨因子并诱导骨形成。虽然大量的研究为软骨发育的调控和功能提供了新的见解，但对调控软骨细胞肥大的细胞内信号通路知之甚少。最近的研究表明，环鸟苷一磷酸(CGMP)依赖的蛋白激酶II(CGKII)将软骨细胞增殖的停止和肥大分化的开始结合在一起。本文就cGKII调控软骨细胞肥大的分子机制以及cGKII与其他信号通路的相互作用作一综述。
During vertebrate skeletal development, the appendicular skeleton forms through endochondral ossification, which involves the intricately regulated multistep differentiation of mesenchymal cells. During this process, mesenchymal condensations initially differentiate into chondrocytes. Then chondrocytes in the center further differentiate into hypertrophic chondrocytes. Hypertrophic chondrocytes express a number of osteogenic factors and induce bone formation. Although numerous studies have provided novel insights into the regulation and function of cartilage development, little is known about the intracellular signaling pathways regulating chondrocyte hypertrophy. Recent study revealed that cyclic guanosine monophosphate (cGMP)-dependent protein kinase II (cGKII) coupled the stop of proliferation and the start of hypertrophic differentiation of chondrocytes. Herein, we review the molecular mechanism of regulation of chondrocyte hypertrophy by cGKII and the interaction between cGKII and other signaling pathways.