Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy.
Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy.
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DOI：
10.1159/000332830
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发表时间：
2011-09
影响因子：
0.4
通讯作者：
Negi A
中科院分区：
文献类型：
--
作者：
Imai H;Honda S;Tsukahara Y;Negi A
目的：报告1例增殖性糖尿病视网膜病变（PDR）患者玻璃体内注射贝伐单抗（IVB）后出现一过性黄斑水肿（ME）和视网膜功能恶化。一例53岁男性患者双眼接受IVB（1.25 mg/0.05 ml）治疗PDR。无治疗相关并发症。然而，他在注射后6小时主诉双眼失明。裂隙灯检查显示双眼前房轻度细胞浸润（1+）。光学相干断层扫描显示左眼ME形成。与治疗前相比，全视野和多焦视网膜电图（ERG）显示双眼所有参数均恶化。注射后1天，眼前节和ME的炎症消失。除左眼多焦ERG的N1和P1振幅外，其余ERG参数在注射后9天均有所改善。我们建议接受IVB的患者应仔细告知并随访可能的并发症，包括暂时性ME形成和视网膜功能恶化。
To report a case of proliferative diabetic retinopathy (PDR) showing transient macular edema (ME) and deteriorated retinal function after intravitreal bevacizumab injection (IVB). A 53-year-old man received IVB (1.25 mg/0.05 ml) in both eyes for the treatment of PDR. There was no treatment-related complication. However, he complained of photopsia in both eyes 6 h after the injection. Slit-lamp examination revealed mild cellular infiltrations (1+) in the anterior chamber in both eyes. Optical coherence tomography showed ME formation in the left eye. Both full-field and multifocal electroretinography (ERG) revealed the deterioration of all parameters in both eyes compared with pretreatment. The inflammation in the anterior segment and ME disappeared 1 day after the injection. ERG parameters were improved 9 days after the injection, except for the N1 and P1 amplitude of multifocal ERG in the left eye. We propose that patients who undergo IVB should be carefully informed and followed up for possible complications including temporal ME formation and retinal function deterioration.