BIOLOGIC FEATURES OF HIV-1 THAT CORRELATE WITH VIRULENCE IN THE HOST
BIOLOGIC FEATURES OF HIV-1 THAT CORRELATE WITH VIRULENCE IN THE HOST
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DOI：
10.1126/science.2832945
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发表时间：
1988-04-01
期刊：
影响因子：
56.9
通讯作者：
LEVY, JA
中科院分区：
文献类型：
--
作者：
CHENGMAYER, C;SETO, D;LEVY, JA
感染人类免疫缺陷病毒1型（HIV-1）的个体可能无症状或患有艾滋病相关综合征或获得性免疫缺陷综合征（AIDS）。人们对影响艾滋病感染进展的因素知之甚少。在这项研究中，在四个人感染期间间隔获得的HIV-1分离株，发现疾病的发展与HIV-1变异体的出现相关，随着疾病的进展，这些变异体在体外更具细胞病变性，并且在各种不同的人类细胞中更有效地复制。因此，HIV-1在体外的生物学特性似乎反映了其在宿主中的毒力。进一步研究这些顺序分离的病毒可能会导致病毒基因的鉴定，控制发病机制。
Individuals infected with the human immunodeficiency virus type 1 (HIV-1) may be asymptomatic or have AIDS-ralated complex or the acquired immuno deficiency syndrome (AIDS). Little is known about the factors that influence progression of infection to AIDS. In this study of isolates of HIV-1 obtained at intervals during the infection of four individuals, the development of disease was found to be correlated with the emergence of HIV-1 variants that were more cytopathic in vitro as the disease progressed and that replicated more efficiently in a wide variety of different human cells. The biologic properties of HIV-1 in vitro thus appear to reflect its virulence in the host. Further studies of such sequentially isolated viruses may lead to the identification of viral genes that govern pathogenesis.