PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients.
PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients.
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DOI：
10.1007/s10147-006-0595-0
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发表时间：
2006-08-01
影响因子：
3.3
通讯作者：
Koyama, Keiko
中科院分区：
文献类型：
--
作者：
Endo, Keigo;Oriuchi, Noboru;Koyama, Keiko
利用葡萄糖的放射性衍生物2-(18)-氟-2-脱氧-D-葡萄糖(FDG)进行正电子发射断层扫描(PET)是一种基于癌细胞葡萄糖消耗增加的先进成像工具。FDG-PET提供了其他成像方式无法获得的信息，在诊断和治疗各种类型的癌症患者中非常有效。但也存在一些局限性，如某些肿瘤摄取FDG较低，炎性细胞摄取FDG较多，缺乏解剖信息，PET成像质量较差。最近开发的一种集成的PET/CT(CT)系统，将PET相机和CT扫描仪结合在一起，通过在同一位置提供解剖和功能成像克服了这些缺点。PET和/或FDG的PET和/或PET/CT在临床上可用于癌症的发现、良恶性病变的鉴别、癌症治疗前的分期和癌症治疗的评估，以及大多数癌症治疗后复发的判断，包括肺癌、胃肠癌、乳腺癌和恶性淋巴瘤。在许多癌症患者的诊断和治疗中，PET/CT已成为新的标准成像方法。
Positron emission tomography (PET) using 2-(18)F-fluoro-2-deoxy-D-glucose (FDG), a radioactive derivative of glucose, is an advanced imaging tool, based on the increased glucose consumption of cancer cells. FDG-PET provides information that is not obtainable with other imaging modalities, and is very effective in the diagnosis and management of patients with various types of cancers. However, there are some limitations, such as low FDG uptake in some cancers, substantial FDG uptake in inflammatory cells, and the lack of anatomical information and poor imaging quality of PET. A recently developed integrated PET/computed tomography (CT) system, which combines a PET camera and CT scanner in a single session, has overcome these drawbacks by providing both anatomical and functional imaging at the same position. PET and/or PET/CT using FDG is clinically useful in the detection of cancer, the differentiation of malignant and benign lesions, the staging of cancer before therapy, and the assessment of cancer therapy, as well as for determining the recurrence after therapy of most cancers, including lung cancer, gastrointestinal cancer, breast cancer, and malignant lymphoma. PET/CT has become the new standard approach to imaging in the diagnosis and management of many cancer patients.