Highlight Commentary on "Influence of lung oxidant and antioxidant status on alveolarization: Role of light-exposed total parenteral nutrition".
Highlight Commentary on "Influence of lung oxidant and antioxidant status on alveolarization: Role of light-exposed total parenteral nutrition".
复制标题
重点评论“肺氧化剂和抗氧化状态对肺泡化的影响：光照射全肠外营养的作用”。
DOI：
10.1016/j.freeradbiomed.2008.05.016
复制
发表时间：
2008
影响因子：
7.4
通讯作者：
Gauthier,TheresaW
中科院分区：
文献类型：
--
作者：
Brown,LouAnnS;Gauthier,TheresaW
支气管肺发育不良（BPD）是早产儿的常见并发症，特别是极低出生体重儿（<1500 g）。毫无疑问，多种机制导致与BPD相关的不良结果，但氧化应激是一个致病因素。在本期《自由基生物学与医学》中，Lavoie等人描述了用于营养支持的复合维生素溶液（全胃肠外营养（TPN））暴露于环境光时过氧化物的产生增加。由于早产儿的抗氧化能力有限，TPN引起的氧化负荷增加变得越来越显著。在新生豚鼠中输注这种暴露于光下的溶液会降低肺组织中的维生素C，但不会降低维生素E。当混合多种维生素和脂质溶液，然后暴露于光下，肺泡发育的肺减少。Lavoie等人的这项研究强调了一些简单的措施，这些措施可能会减少输送给这一脆弱人群的氧化剂负荷，并改善肺泡化。
Bronchopulmonary dysplasia (BPD) is a frequent complication of premature newborns, particularly very low birth-weight babies (<1500 g). Undoubtedly multiple mechanisms contribute to the adverse outcomes associated with BPD but oxidative stress is one causative factor. In this issue of Free Radical Biology and Medicine, Lavoie et al. describe the increased peroxide generation when the multivitamin solution used for nutritional support, total parenteral nutrition (TPN), is exposed to ambient light. Because the premature newborn has limited antioxidant capacity, this increased oxidative burden from the TPN becomes increasingly significant. Infusion of this light-exposed solution in a newborn guinea pig decreased lung tissue vitamin C but not vitamin E. When the multivitamin and lipid solutions were mixed and then exposed to light, alveolarization of the developing lung was decreased. This study by Lavoie et al. highlights simple measures that can potentially decrease the oxidant burden delivered to this vulnerable population and improve alveolarization.