Scopolamine- and morphine-induced impairments of spontaneous alternation performance in mice: reversal with glucose and with cholinergic and adrenergic agonists.
Scopolamine- and morphine-induced impairments of spontaneous alternation performance in mice: reversal with glucose and with cholinergic and adrenergic agonists.
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DOI：
10.1037/0735-7044.105.2.264
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发表时间：
1991-04
影响因子：
1.9
通讯作者：
W. Stone;B. Walser;Sigfried Gold;P. E. Gold
中科院分区：
文献类型：
--
作者：
W. Stone;B. Walser;Sigfried Gold;P. E. Gold
服用肾上腺素和葡萄糖以及影响胆碱能和阿片系统的药物可以增强或损害记忆。目前的实验检验了外周葡萄糖给药可能逆转东莨菪碱和吗啡在自发交替任务中引起的损伤的可能性。小鼠在测试前 30 分钟接受所有药物给药。东莨菪碱（3 mg/kg）引起的交替表现缺陷可被葡萄糖（100 和 250 mg/kg）、安非他明（1 mg/kg）、肾上腺素、毒扁豆碱和氧化震颤素（各 0.1 mg/kg）逆转。吗啡（10 毫克/千克）也会损害自发交替性能，而葡萄糖（100 和 300 毫克/千克）也可以逆转这种损害。这些发现与以下观点一致：中枢胆碱能系统可能在阿片类药物的抑制性调节下，可能导致葡萄糖和肾上腺素对记忆存储的影响。
Administration of epinephrine and glucose, as well as drugs that influence cholinergic and opiate systems, can enhance or impair memory. The present experiments examined the possibility that peripheral glucose administration might reverse scopolamine- and morphine-induced impairments in a spontaneous alternation task. Mice received all drug administrations 30 min before testing. Scopolamine-induced (3 mg/kg) deficits in alternation performance were reversed by glucose (100 and 250 mg/kg), amphetamine (1 mg/kg), epinephrine, physostigmine, and oxotremorine (each 0.1 mg/kg). Morphine (10 mg/kg) also impaired spontaneous alternation performance, and glucose (100 and 300 mg/kg) reversed this impairment as well. These findings are consistent with the view that central cholinergic systems, possibly under inhibitory opiate regulation, may contribute to glucose and epinephrine effects on memory storage.