Microscopy techniques for investigating the control of organic constituents on biomineralization.
Microscopy techniques for investigating the control of organic constituents on biomineralization.
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DOI：
10.1557/mrs.2015.98
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发表时间：
2015-06
期刊：
影响因子：
5
通讯作者：
Estroff LA
中科院分区：
文献类型：
--
作者：
Hendley CT 4th;Tao J;Kunitake JA;De Yoreo JJ;Estroff LA
本文介绍了应用显微技术表征结晶过程的最新进展，因为它们与生物矿化和生物启发的材料合成有关。特别是，我们专注于旨在揭示有机大分子和官能化表面在调控成核和生长机制中所起作用的研究。在成核研究中，我们探索了利用原位电子显微镜、原子力显微镜和低温电子显微镜等方法来描绘形成途径、相稳定以及自由能和动能垒的竞争效应。在生长研究中，重点是了解大分子组分与生长晶体的相互作用，并使用电子断层扫描、原子探针断层扫描和振动光谱显微镜等技术表征所得到的复合晶体的内部结构。这些例子既来自生物系统，也来自生物灵感合成系统。
This article addresses recent advances in the application of microscopy techniques to characterize crystallization processes as they relate to biomineralization and bio-inspired materials synthesis. In particular, we focus on studies aimed at revealing the role organic macromolecules and functionalized surfaces play in modulating the mechanisms of nucleation and growth. In nucleation studies, we explore the use of methods such as in situ transmission electron microscopy, atomic force microscopy, and cryogenic electron microscopy to delineate formation pathways, phase stabilization, and the competing effects of free energy and kinetic barriers. In growth studies, emphasis is placed on understanding the interactions of macromolecular constituents with growing crystals and characterization of the internal structures of the resulting composite crystals using techniques such as electron tomography, atom probe tomography, and vibrational spectromicroscopy. Examples are drawn from both biological and bio-inspired synthetic systems.