Association of renin and aldosterone with ethnicity and blood pressure: the Multi-Ethnic Study of Atherosclerosis.
Association of renin and aldosterone with ethnicity and blood pressure: the Multi-Ethnic Study of Atherosclerosis.
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肾素和醛固酮与种族和血压的关联：动脉粥样硬化的多种族研究。
DOI：
10.1093/ajh/hpt276
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发表时间：
2014
影响因子：
3.2
通讯作者：
Allison,MatthewA
中科院分区：
文献类型：
--
作者：
Rifkin,DenaE;Khaki,AliR;Jenny,NancyS;McClelland,RobynL;Budoff,Matthew;Watson,Karol;Ix,JoachimH;Allison,MatthewA
研究背景虽然在白人和黑人中检测了血浆肾素活性（PRA）和醛固酮的变化，但在多种族人群中这些激素与血压的关系还没有被描述。021名参与多种族动脉粥样硬化研究的未服用抗高血压药物的受试者，并检查了种族与PRA/醛固酮之间的关系以及PRA/醛固酮之间的关系。醛固酮与收缩压（SBP）的关系。研究对象年龄为62岁（SD = 9），49%的参与者为女性。中位PRA为0.51（四分位距（IQR）= 0.29-0.87）ng/ml/h，中位醛固酮为12.6（IQR = 9.1-17.1）ng/dl。调整年龄和性别后，与白人相比，黑人的PRA低28%，醛固酮低17.4%，西班牙裔的PRA高20.1%，但醛固酮水平相似。多变量校正后，与白人相比，只有西班牙裔与较高的PRA独立相关（0.18 ng/ml/h; 95%置信区间（CI）= 0.06-0.31）。与白人相比，黑人的醛固酮水平较低（-1.7ng/dl; 95%CI =-3.2至0.2）。多变量校正后，PRA与白人（-3.2 mmHg; 95% CI =-5.2至1.2每标准化单位PRA）、中国人（-3.5 mmHg; 95% CI =-6.2至0.80每标准化单位PRA）和西班牙裔（-2.3 mmHg; 95% CI =-4.1至0.6每标准化单位PRA）的较低SBP相关，但与黑人无关。醛固酮仅与西班牙裔的高收缩压相关（2.5mmHg; 95%CI = 0.4-4.5 per SD）。与其他人群相比，西班牙裔人群中醛固酮与较高的SBP显著相关，这一发现可能提示高血压的不同机制。
BACKGROUNDAlthough variations in plasma renin activity (PRA) and aldosterone have been examined in whites and blacks, the association of these hormones with blood pressure in multiethnic populations has not been described.METHODSWe measured PRA and aldosterone in 1,021 participants in the Multi-Ethnic Study of Atherosclerosis not taking antihypertensives and examined the association between ethnicity and PRA/aldosterone and the association between PRA/aldosterone with systolic blood pressure (SBP).RESULTSAverage age was 62 (SD = 9) years, and 49% of participants were women. Median PRA was 0.51 (interquartile range (IQR) = 0.29–0.87) ng/ml/hour, and median aldosterone was 12.6 (IQR = 9.1–17.1) ng/dl. After age and sex adjustment, compared with whites, blacks had 28% lower PRA and 17.4% lower aldosterone, and Hispanics had 20.1% higher PRA but similar aldosterone levels. After multivariable adjustment, compared with whites, only Hispanic ethnicity independently associated with higher PRA (0.18ng/ml/hour; 95% confidence interval (CI) = 0.06–0.31). Blacks had lower aldosterone (−1.7ng/dl; 95% CI = −3.2 to −0.2) compared with whites. After multivariable adjustment, PRA was associated with lower SBP in whites (−3.2mm Hg; 95% CI = −5.2 to −1.2 per standardized unit PRA), Chinese (−3.5mm Hg; 95% CI = −6.2 to −0.80 per standardized unit), and Hispanics (−2.3mm Hg; 95% CI = −4.1 to −0.6 per standardized unit) but not blacks. Aldosterone was associated with higher SBP only in Hispanics (2.5mm Hg; 95% CI = 0.4–4.5 per SD).CONCLUSIONSCompared with whites, blacks have lower aldosterone and Hispanics have higher PRA. Aldosterone had significant associations with higher SBP in Hispanics compared with other groups, a finding that may suggest a different mechanism of hypertension.
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影响因子：
158.5
作者：
ALDERMAN, MH;MADHAVAN, S;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
39.3
作者：
de Boer, Rudolf A.;Schroten, Nicolas F.;Hillege, Hans L.
通讯作者：
Hillege, Hans L.
影响因子：
3.2
作者：
Sim, John J.;Bhandari, Simran K.;Laragh, John H.
通讯作者：
Laragh, John H.
影响因子：
13.2
作者：
Stevens, Lesley A.;Coresh, Josef;Levey, Andrew S.
通讯作者：
Levey, Andrew S.
影响因子：
39.3
作者：
Verma, Subodh;Gupta, Milan;Lonn, Eva M.
通讯作者：
Lonn, Eva M.