Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults
Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults
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炎症对主观社会地位影响的性别差异：健康年轻人内毒素的随机对照试验
DOI：
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发表时间：
2019
影响因子：
3.8
通讯作者：
N. Eisenberger
中科院分区：
文献类型：
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作者：
Mona Moieni;K. A. Muscatell;I. Jevtić;E. Breen;M. Irwin;N. Eisenberger
人们已经确定，炎症会导致社会经验的各种变化，但社会经验中被忽视的一个领域是主观社会地位。此外，鉴于炎症和社会地位之间关系的性别差异，男性可能对炎症引起的社会地位变化更敏感。然而，以前的人类研究没有研究过这种可能性。在本研究中，健康的年轻参与者（n = 115）被随机分配接受内毒素，实验性炎症挑战，或安慰剂。参与者在基线（注射前）和大约2小时后（内毒素组炎症反应峰值时间）报告了他们的主观社会状态。使用ANCOVA分析的结果表明，暴露于内毒素的男性（而非女性）在炎症反应高峰时报告的主观社会地位水平较低（与安慰剂相比）。这些结果表明，男性可能对某些社会领域的炎症影响更敏感，例如感知的社会地位。临床试验注册：www.ClinicalTrials.gov，标识符NCT 01671150。
It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status. Furthermore, given sex differences in the relationship between inflammation and social status, males may be more sensitive to inflammation-induced changes in social status. However, no previous studies in humans have examined this possibility. In the present study, healthy young participants (n = 115) were randomly assigned to receive either endotoxin, an experimental inflammatory challenge, or placebo. Participants reported their subjective social status at baseline (prior to injection), and approximately 2 h later (time of peak inflammatory response for the endotoxin group). Results, using ANCOVA analyses, indicated that males exposed to endotoxin, but not females, reported lower levels of subjective social status at the peak of inflammatory response (vs. placebo). These results suggest that males may be more sensitive to the effects of inflammation in certain social domains, such as perceived social status. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01671150.