Test profile of cholinergic dysfunction and of Alzheimer-type dementia.
Test profile of cholinergic dysfunction and of Alzheimer-type dementia.
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胆碱能功能障碍和阿尔茨海默型痴呆的测试概况。
DOI：
10.1080/01688638408401229
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
P. Fuld
中科院分区：
文献类型：
--
作者：
P. Fuld
韦氏成人智力量表（WAIS）的亚测试得分特征与临床测试的痴呆患者相似，在19名药物引起的精神功能胆碱能缺乏症的正常青年受试者中发现了10名，而在22名对照受试者中仅发现了4名。然后在两组连续痴呆患者（分别为61和77例）的测试数据中发现了相同的亚测试特征，这些患者的研究诊断为阿尔茨海默型痴呆（DAT，老年和老年性痴呆），多发性梗死和其他痴呆。该分析确定了44%可检测的AD患者，96%特异于DAT（只有两个假阳性）。言语表现智商差异在15分或以上与正常药物受试者的胆碱能功能障碍有关，但这种智商得分差异并不能区分阿尔茨海默氏症和多梗死性痴呆患者。由此得出结论，子测试谱可以有助于DAT与其他痴呆的区分。这种情况与药物诱导的胆碱能缺乏的关联表明，DAT胆碱能缺乏可能是这种疾病中所见的智力变化的原因。
A characteristic profile of subtest scores from the Wechsler Adult Intelligence Scale (WAIS) similar to that seen in clinically tested dementia patients was found in 10 of 19 normal young adult subjects with a drug-induced cholinergic deficiency of mental functioning but in only 4 of 22 control subjects. The same subtest profile was then found in test data from two groups of consecutive dementia patients (61 and 77 patients, respectively) with research diagnoses of Alzheimer-type dementia (DAT, senile and presenile), multi-infarct, and other dementias. The profile identified 44% of testable patients with AD and was 96% specific to DAT (only two false positives). A Verbal-Performance IQ discrepancy of 15 or more points was associated with cholinergic dysfunction in the normal drug subjects, but this IQ-score discrepancy did not differentiate AD from multi-infarct dementia patients. It was concluded that the subtest profile could contribute to the differentiation of DAT from other dementias. The association of this profile with drug-induced cholinergic deficiency suggested that the cholinergic deficiency of DAT might be responsible for the intellectual changes seen in this disease.