Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review
Electrically Controlled Biochemical Release from Micro/Nanostructures for in vitro and in vivo Applications: A Review
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DOI：
10.1002/cnma.201800157
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发表时间：
2018-06
期刊：
影响因子：
3.8
通讯作者：
Jianhe Guo;D. Fan
中科院分区：
文献类型：
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作者：
Jianhe Guo;D. Fan
以可控的速率在规定的细胞和组织位置释放生物物质，包括药物分子、DNA 和蛋白质，是药物输送的圣杯，它可以实现一系列前所未有的体外和体内应用。广泛的研究工作集中在探索以规定的剂量、时间和动力学控制生化释放的创新机制和方法。特别是，利用电场刺激合成微/纳米结构释放生物分子引起了人们极大的兴趣。在这篇综述中，我们重点关注通过多种机制利用电场控制生物分子释放的最新进展，包括电化学解吸和驱动、电触发腐蚀以及电驱动纳米泵和机械运动。外部电刺激触发生物释放的研究进展迅速，可能对单细胞生物学、细胞间通讯和药物发现产生显着影响。
To release biosubstances, including drug molecules, DNAs, and proteins, at prescribed cellular and tissue locations with controllable rates is the Holy Grail of drug delivery that could enable an array of unprecedentedin vitroandin vivoapplications. Extensive research efforts have been focused on exploring innovative mechanisms and approaches for controlling biochemical release with prescribed dose, timing, and dynamics. Particularly, the utilization of electric fields to stimulate the release of biomolecules from synthesized micro/nanostructures has received considerable interest. In this review, we focus on the recent progresses in controlling the release of biomolecules with electric fields by a variety of mechanisms, including electrochemical desorption and actuation, electrically triggered erosion, and electrically driven nanopumps and mechanical motions. The research on external electric stimuli trigged biorelease has progressed rapidly and could make remarkable impact in single‐cell biology, cell‐cell communication, and drug discovery.