The effect of a layer-by-layer chitosan-heparin coating on the endothelialization and coagulation properties of a coronary stent system
The effect of a layer-by-layer chitosan-heparin coating on the endothelialization and coagulation properties of a coronary stent system
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DOI：
10.1016/j.biomaterials.2008.12.075
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发表时间：
2009-04-01
期刊：
影响因子：
14
通讯作者：
Ge, Junbo
中科院分区：
文献类型：
--
作者：
Meng, Sheng;Liu, Zongjun;Ge, Junbo
壳聚糖/肝素在冠状动脉支架上的生物大分子逐层涂层工艺旨在加速冠状动脉支架部署后的再内皮化和愈合过程。猪髂动脉内皮细胞的体外培养以及APTT、PT和TT的测量结果支持了壳聚糖和肝素的组合可以为支架表面带来内皮细胞相容性和血液相容性的理论依据。采用猪冠状动脉损伤模型和动静脉分流模型进一步评价该种表面改性不锈钢支架在体内的应用。最终结果证明，这种简便的涂层方法可以显着促进再内皮化，并且与裸金属支架相比更安全，其抗凝性能大大提高。 (C) 2009 Elsevier Ltd. 保留所有权利。
A biomacromolecular layer-by-layer coating process of chitosan/heparin onto a coronary stent is designed for the acceleration of the re-endothelialization and healing process after coronary stent deployment. The results of in vitro culturing of porcine iliac artery endothelial cells as well as the measurements of the APTT, PT and TT supported the rationale that the combination of chitosan and heparin could bring both endothelial cell compatibility and haemocompatibility to the stent surface. A porcine coronary injury model and arteriovenous shunt model were used for the further evaluation of the application of this kind of surface-modified stainless steel stent in vivo. The final results proved that this facile coating approach could significantly promote re-endothelialization and was safer compared with bare metal stents for its much improved anticoagulation property. (C) 2009 Elsevier Ltd. All rights reserved.