REGULATION OF CUTANEOUS PREVITAMIN-D3 PHOTOSYNTHESIS IN MAN - SKIN PIGMENT IS NOT AN ESSENTIAL REGULATOR
REGULATION OF CUTANEOUS PREVITAMIN-D3 PHOTOSYNTHESIS IN MAN - SKIN PIGMENT IS NOT AN ESSENTIAL REGULATOR
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DOI：
10.1126/science.6256855
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
DOPPELT, SH
中科院分区：
文献类型：
--
作者：
HOLICK, MF;MACLAUGHLIN, JA;DOPPELT, SH
当人体皮肤暴露在模拟太阳紫外线辐射下时，表皮7-脱氢胆固醇转化为维生素D3原。在长时间暴露于模拟太阳紫外线辐射下时，维生素D3原的合成在约0.47时达到平台期。原始7-脱氢胆固醇含量的10-15%和维生素D3原被光异构化为2种生物惰性异构体，lumisterol3和tachysterol3。皮肤黑色素浓度的增加或纬度的增加，需要增加模拟太阳紫外线辐射的暴露时间，以最大限度地形成维生素D3原，但不是总含量。按重要性排序，限制皮肤产生维生素D3前的重要决定因素是光化学调节、色素沉着和纬度。
When human skin was exposed to simulated solar UV radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar UV radiation, the synthesis of previtamin D3 reached a plateau at .apprx. 10-15% of the original 7-dehydrocholesterol content and previtamin D3 was photoisomerized to 2 biologically inert isomers, lumisterol3 and tachysterol3. Increases in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar UV radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are photochemical regulation, pigmentation and latitude.