Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
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DOI：
10.1016/j.cclet.2010.12.048
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发表时间：
2011-06
影响因子：
9.1
通讯作者：
HaiYang Liu;Kun Wang;Hai-yan Fu;Mao-Lin Yuan;Hua Chen;Ruixiang Li
中科院分区：
文献类型：
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作者：
HaiYang Liu;Kun Wang;Hai-yan Fu;Mao-Lin Yuan;Hua Chen;Ruixiang Li
合成了一种价廉的、空气稳定的由脯氨酸衍生的酰胺，其结构经1H核磁共振、13C核磁共振和MS表征，是钯催化的Suzuki交叉偶联反应中的一种有效配体。在Pd/酰胺催化体系中，芳基溴化物和苯基硼酸在乙醇/水(1：2；v/v)中可以很好地偶联，即使Pd的负载量很低，也只有0.01nmol%。而且，反应范围广，各种官能团都具有耐受性。
Amide, which is derived from proline and is inexpensive and air-stable, has been synthesized and characterized by1H NMR,13C NMR, and MS. It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction. In the Pd/amide catalytic system, aryl bromides can be coupled with phenylboronic acid in ethanol/water (1:2; v/v) in excellent yields even with a low Pd loading of 0.01 mol%. Moreover, the scope of the reaction is broad, and a wide variety of functional groups are tolerant.