Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil
Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil
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DOI：
10.1111/j.1365-4632.2011.05282.x
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发表时间：
2012-12-01
影响因子：
3.6
通讯作者：
De Zorzi Pinto, Angela C.
中科院分区：
文献类型：
--
作者：
de Carvalho, Andre V. E.;Bonamigo, Renan R.;De Zorzi Pinto, Angela C.
背景 肾移植患者非黑色素瘤皮肤癌（NMSC）的发病率较高。先前的研究假设人类白细胞抗原 (HLA)，尤其是 DR1、DR4 和 DR7 型，可能会影响这些肿瘤的发病率。本研究调查了巴西南部肾移植患者中 NMSC 与 HLA DR1、DR4 和 DR7 存在之间的关联。方法在一项历史队列研究中，对1993年1月至2006年12月期间接受肾移植的1032名患者进行了检查，以确定移植前NMSC和HLA状态的发生情况。结果 在接受检查的 1032 名患者中，59 名（5.71%）发生 NMSC（鳞状细胞癌 [SCC]：2.42%；基底细胞癌 [BCC]：1.74%；两者：1.55%）。 HLA DR1 的存在与发生任何 NMSC 的较高可能性相关，特别是与发生 BCC 的可能性相关 (P < 0.05)。该样本中 HLA DR4 或 DR7 的存在与 NMSC 的发生之间没有统计学上的显着关联。结论 HLA DR1 似乎与 BCC 的发生以及肾移植患者 NMSC 病变数量较多有关。这项研究支持将 DR1 等位基因与 BCC 而不是 SCC 相关联的趋势。
Background Renal transplant patients have a higher incidence of non-melanoma skin cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA), especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This study investigates the association between NMSC and the presence of HLA DR1, DR4, and DR7 in renal transplant patients in southern Brazil. Methods In a historical cohort study, 1032 patients who underwent renal transplantation during the period from January 1993 to December 2006 were examined to identify occurrences of NMSC and HLA status prior to transplant. Results Of the 1032 patients examined, 59 (5.71%) developed NMSC (squamous cell carcinoma [SCC]: 2.42%; basal cell carcinoma [BCC]: 1.74%; both: 1.55%). The presence of HLA DR1 was associated with a higher probability of developing any NMSC and particularly with developing BCC (P < 0.05). There was no statistically significant association between the presence of HLA DR4 or DR7 and the occurrence of NMSC in this sample. Conclusions HLA DR1 appears to be associated with the development of BCC, as well as with the higher number of NMSC lesions in renal transplant patients. This study supports the trend to associate the DR1 allele with BCC and not with SCC.