GBV-C infection and risk of NHL among U.S. adults.
GBV-C infection and risk of NHL among U.S. adults.
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DOI：
10.1158/0008-5472.can-14-0209
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发表时间：
2014-10-01
期刊：
影响因子：
11.2
通讯作者：
Engels EA
中科院分区：
文献类型：
--
作者：
Chang CM;Stapleton JT;Klinzman D;McLinden JH;Purdue MP;Katki HA;Engels EA
一些回顾性研究表明，与GB-病毒C（GBV-C）和非霍奇金淋巴瘤（NHL）之间的关联感染。我们在美国前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验（PLCO）的巢式病例对照研究中前瞻性评估了这种关联。病例组（N=658）和对照组（N= 1，316）按年龄、性别、人种/种族、研究入组时间和样本选择进行个体匹配。对诊断前PLCO血清样本进行GBV-C RNA（作为活动性感染的指标）和E2抗体（活动性或消退感染）检测。Logistic回归用于估计GBV-C与NHL总体和NHL亚型之间相关性的比值比（OR）。GBV-C RNA阳性12例（1.8%），对照组7例（0.5%）。GBV-C RNA阳性与NHL总体相关（OR=3.43，95% CI=1.35-8.71），基于少量病例，与弥漫性大B细胞淋巴瘤相关（OR=5.31，95% CI=1.54-18.36）。当检测和选择之间的间隔大于4年时，与NHL的相关性持续存在（OR=6.00，95%CI = 1.21-29.73）。相反，E2抗体阳性与NHL风险无关（OR=1.08，95%CI =0.74-1.58）。我们的研究表明GBV-C感染先于NHL的发展。GBV-C感染可能在一小部分NHL病例中起病因作用，可能是通过引起慢性免疫刺激或免疫监视受损。
Some retrospective studies suggest an association between infection with GB-virus C (GBV-C) and non-Hodgkin lymphoma (NHL). We evaluated this association prospectively in a nested case-control study within the U.S. Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). Cases (N=658) and controls (N=1,316) were individually-matched by age, sex, race/ethnicity, timing of study entry and sample selection. Pre-diagnostic PLCO serum samples were tested for GBV-C RNA (as a measure of active infection) and E2 antibody (active or resolved infection). Logistic regression was used to estimate odds ratios (ORs) for the association between GBV-C and NHL overall and NHL subtypes. Twelve cases (1.8%) and 7 controls (0.5%) were GBV-C RNA positive. GBV-C RNA positivity was associated with NHL overall (OR=3.43, 95% CI=1.35-8.71) and, based on small numbers, diffuse large B-cell lymphoma (OR=5.31, 95% CI=1.54-18.36). The association with NHL persisted when the interval between testing and selection was greater than 4 years (OR=6.00, 95% CI= 1.21-29.73). In contrast, E2 antibody-positivity was not associated with NHL risk (OR=1.08, 95% CI=0.74-1.58). Our study demonstrates that GBV-C infection precedes development of NHL. GBV-C infection may play an etiologic role in a small proportion of NHL cases, perhaps by causing chronic immune stimulation or impaired immunosurveillance.