Time-to-Event Analysis of Fine Particle Air Pollution and Preterm Birth: Results From North Carolina, 2001-2005
Time-to-Event Analysis of Fine Particle Air Pollution and Preterm Birth: Results From North Carolina, 2001-2005
复制标题
DOI：
10.1093/aje/kwr403
复制
发表时间：
2012-01-15
影响因子：
5
通讯作者：
Miranda, Marie Lynn
中科院分区：
文献类型：
--
作者：
Chang, Howard H.;Reich, Brian J.;Miranda, Marie Lynn
怀孕期间暴露于空气污染被认为是早产的一个危险因素;然而，流行病学证据仍然是混合和有限的。作者研究了2001-2005年期间北卡罗来纳州空气动力学直径< 2.5 μ m的颗粒物（PM2.5）的环境水平与早产风险之间的关系。他们通过两阶段离散时间生存模型估计了怀孕期间累积和滞后平均暴露于PM2.5的风险。作者还考虑了来自以下方面的暴露指标：1）空气质量系统（AQS）监测网络测量的环境浓度，2）通过统计融合AQS数据与基于过程的数值模型输出（统计融合空气和沉积表面（FSD）数据库）预测的浓度。使用AQS测量，累积PM2.5暴露的四分位数范围（1.73 μ g/m3）增加与早产风险增加6.8%（95%后验间隔：0.5，13.6）相关。使用FSD预测的水平并考虑预测误差，作者还发现妊娠1、妊娠2和累积PM2.5暴露与早产之间存在显著的不良关联。这些发现表明，即使在空气质量相对较好的地区，怀孕期间暴露于环境PM2.5也与早产风险增加有关。
Exposure to air pollution during pregnancy has been suggested to be a risk factor for preterm birth; however, epidemiologic evidence remains mixed and limited. The authors examined the association between ambient levels of particulate matter < 2.5 mu m in aerodynamic diameter (PM2.5) and the risk of preterm birth in North Carolina during the period 2001-2005. They estimated the risks of cumulative and lagged average exposures to PM2.5 during pregnancy via a 2-stage discrete-time survival model. The authors also considered exposure metrics derived from 1) ambient concentrations measured by the Air Quality System (AQS) monitoring network and 2) concentrations predicted by statistically fusing AQS data with process-based numerical model output (the Statistically Fused Air and Deposition Surfaces (FSD) database). Using the AQS measurements, an interquartile-range (1.73 mu g/m(3)) increase in cumulative PM2.5 exposure was associated with a 6.8% (95% posterior interval: 0.5, 13.6) increase in the risk of preterm birth. Using the FSD-predicted levels and accounting for prediction error, the authors also found significant adverse associations between trimester 1, trimester 2, and cumulative PM2.5 exposure and preterm birth. These findings suggest that exposure to ambient PM2.5 during pregnancy is associated with increased risk of preterm birth, even in a region characterized by relatively good air quality.