The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma
The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma
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DOI：
10.1111/j.1365-2559.2009.03379.x
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发表时间：
2009-09-01
期刊：
影响因子：
6.4
通讯作者：
Busund, Lill-Tove
中科院分区：
文献类型：
--
作者：
Al-Shibli, Khalid;Al-Saad, Samer;Busund, Lill-Tove
目的：在有可能治愈的非小细胞肺癌（NSCLC）中，预后标志物的主要价值应该是指导手术切除后的治疗。肿瘤浸润性巨噬细胞，其生长因子，巨噬细胞集落刺激因子（M-CSF），及其受体，集落刺激因子-1受体（CSF-1 R），以及自然杀伤细胞和树突状细胞的预后意义是有争议的。本研究的目的是阐明这些标志物在上皮和间质舱室NSCLC的预后意义。方法和结果：组织芯片从335切除的NSCLC，阶段I-IIIA构建从重复的核心上皮和间质区。采用免疫组织化学法评价上皮和间质区域的CD 68、M-CSF、CSF-1 R、CD 56和CD 1a。在单变量分析中，间质CD 1a+（P = 0.011）和CD 56+细胞（P = 0.014）数量的增加与疾病特异性生存期（DSS）的改善显著相关。多因素分析显示，间质CD 56+细胞是DSS的独立预后因素（风险比= 2.3，置信区间= 1.1，5.0，P = 0.031）。结论：间质CD 56+细胞的高密度是一个独立的因素与改善预后切除NSCLC，这表明这些细胞介导的抗肿瘤免疫反应在肿瘤间质。
Aims:The major value of prognostic markers in potentially curable non-small cell lung carcinoma (NSCLC) should be to guide therapy after surgical resection. The prognostic significance of tumour-infiltrating macrophages, their growth factor, macrophage colony-stimulating factor (M-CSF), and its receptor, colony-stimulating factor-1 receptor (CSF-1R), as well as natural killer cells and dendritic cells, is controversial. The aim of this study was to elucidate the prognostic significance of these markers in the epithelial and stromal compartments of NSCLC.Methods and results:Tissue microarrays from 335 resected NSCLC, stage I-IIIA were constructed from duplicate cores of epithelial and stromal areas. Immunohistochemistry was used to evaluate epithelial and stromal areas for CD68, M-CSF, CSF-1R, CD56 and CD1a. On univariate analysis, increasing numbers of stromal CD1a+ (P = 0.011) and CD56+ cells (P = 0.014) correlated significantly with improved disease-specific survival (DSS). On multivariate analysis, stromal CD56+ cells were an independent prognostic factor for DSS (hazard ratio = 2.3, confidence interval = 1.1, 5.0, P = 0.031).Conclusions:High density of stromal CD56+ cells is an independent factor associated with improved prognosis in resected NSCLC, suggesting that these cells mediate an antitumour immune response in the tumour stroma.