Rule-dependent activity for prosaccades and antisaccades in the primate prefrontal cortex
Rule-dependent activity for prosaccades and antisaccades in the primate prefrontal cortex
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DOI：
10.1162/0898929054985455
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发表时间：
2005-09-01
影响因子：
3.2
通讯作者：
DeSouza, JFX
中科院分区：
文献类型：
--
作者：
Everling, S;DeSouza, JFX
日常生活通常需要的行为远远超过简单的刺激-反应关联。环境线索往往是模糊的，需要根据情况采取不同的行动。前额叶皮层（PFC）被认为是这种灵活控制行为的关键。一个重要的任务，探测这种能力是antisaccade任务中，受试者必须抑制一眼突然出现的周边刺激，而不是从刺激看它的镜像位置。在这里，我们记录了PFC神经元的活动在猴子训练之间交替块的正面和反的试验没有外部指令线索。我们发现，许多神经元的活动是不同的两个任务之间的固定期之前，周围刺激。这些差异在任务转换后的第一次正确试验中就已经存在。这些神经元的活动也区分正确的反应和错误。我们假设，PFC提供偏置信号，眼跳相关的领域，是必要的预设不同的任务的眼视系统。
Everyday life typically requires behavior that involves far more than simple stimulus-response associations. Environmental cues are often ambiguous and require different actions depending on the situation. The prefrontal cortex (PFC) is thought to be crucial for this flexible control of behavior. An important task that probes this ability is the antisaccade task in which subjects have to suppress a glance towards a suddenly presented peripheral stimulus and instead look away from the stimulus to its mirror location. Here we recorded the activity of PFC neurons in monkeys trained to alternate between blocks of prosaccade and antisaccade trials with no external instruction cues. We found that the activity of many neurons was different between the two tasks during the fixation period before the peripheral stimulus was presented. These differences were already present on the first correct trials after a task switch. The activity of these neurons also discriminated between correct responses and errors. We hypothesize that the PFC provides bias signals to saccade-related areas that are necessary to preset the oculomotor system for different tasks.