Pharmacologic Treatment of Apathy in Dementia
Pharmacologic Treatment of Apathy in Dementia
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DOI：
10.1097/jgp.0b013e31822001a6
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发表时间：
2012-02-01
影响因子：
7.2
通讯作者：
Seeher, Katrin
中科院分区：
文献类型：
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作者：
Berman, Karen;Brodaty, Henry;Seeher, Katrin
痴呆患者的冷漠很常见，但未被充分认识和治疗。我们试图通过对使用冷漠结局量表来记录冷漠药物治疗结果的研究进行系统的文献回顾，以提高对痴呆患者冷漠药物治疗的理解。有有限的证据表明药物治疗对痴呆患者冷漠的疗效。乙酰胆碱酯酶抑制剂效果最好。有一些证据表明zemantine有效，但对兴奋剂，钙拮抗剂和抗精神病药物的有效性证据较少。没有证据支持使用抗抑郁药或抗惊厥药。研究的研究质量一般。提出了规范研究、全面评价和治疗的建议。（老年精神病学杂志2012；20:104-122）
Apathy in patients with dementia is common, underrecognized, and undertreated. We sought to improve understanding of the pharmacologic treatment of apathy in dementia by performing a systematic literature review of studies that used apathy outcome scales to document results of pharmacologic treatments for apathy. There is limited evidence of efficiency of phctrmacotherapy for treatment of apathy in dementia. The best results were found for acetylcholinesterase inhibitors. There was some evidence of efficacy for nzemantine, but less evidence of efficacy for stimulants, calcium antagonists, and antipsychotics. There was no evidence to support the use of antidepressants or anticonvulsants. The research quality of studies was modest. Recommendations for standardizing research and for holistic evaluation and treatment are provided. (Am J Geriatr Psychiatry 2012; 20:104-122)