EBV-infected B cells in infectious mononucleosis:: Viral strategies for spreading in the B cell compartment and establishing latency
EBV-infected B cells in infectious mononucleosis:: Viral strategies for spreading in the B cell compartment and establishing latency
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DOI：
10.1016/s1074-7613(00)00048-0
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发表时间：
2000-10-01
期刊：
影响因子：
32.4
通讯作者：
Küppers, R
中科院分区：
文献类型：
--
作者：
Kurth, J;Spieker, T;Küppers, R
人类感染EB病毒可引起传染性单核细胞增多症。对IM患者扁桃体单个EB病毒感染细胞进行重排免疫球蛋白基因分析，揭示了EB病毒在B细胞室快速和大规模传播的两种策略：直接感染许多幼稚的以及记忆和/或生发中心的B细胞，并将后者扩增为大克隆。在IM中，通过生发中心反应从幼稚的B细胞产生携带病毒的记忆B细胞可能没有作用。克隆成员可以表现出不同的形态和可能的EBV基因表达模式，这种能力暗示了一种机制，通过这种机制，携带EBV的细胞可以逃避免疫监视，并建立一个持续感染EBV的B细胞池。
Infection of humans with Epstein-Barr virus (EBV) may cause infectious mononucleosis (IM). Analysis of single EBV-infected cells from tonsils of IM patients for rearranged immunoglobulin genes revealed two strategies of EBV for rapid and massive spread in the B cell compartment: the direct infection of many naive as well as memory and/or germinal center B cells and the expansion of the latter cells to large clones. In IM, the generation of virus-harboring memory B cells from naive B cells passing through a germinal center reaction likely plays no role. Members of clones can show distinct morphologies and likely also EBV gene expression patterns, and this ability implies a mechanism by which EBV-harboring cells can evade immune surveillance and establish a pool of persisting EBV-infected B cells.