Regulation of the SREBP transcription factors by mTORC1
Regulation of the SREBP transcription factors by mTORC1
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DOI：
10.1042/bst0390495
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发表时间：
2011-04-01
影响因子：
3.9
通讯作者：
Schulze, Almut
中科院分区：
文献类型：
--
作者：
Lewis, Caroline A.;Griffiths, Beatrice;Schulze, Almut
近年来，一些报道将mTORC 1（哺乳动物雷帕霉素靶蛋白复合物1）通过SREBP（固醇调节元件结合蛋白）与脂肪生成联系起来。SREBP调节编码脂肪酸和胆固醇生物合成所需的酶的基因的表达。脂质代谢在一些疾病中受到干扰，并且SREBP靶基因，如FATCH（脂肪酸合酶），已显示在一些癌症中上调。我们先前已经证明mTORC 1在SREBP激活和Akt/PKB（蛋白激酶B）依赖性从头脂肪生成中起作用。我们的研究结果表明，mTORC 1在SREBP的激活中起着至关重要的作用，并且通过诱导SREBP来激活脂质生物合成可能是细胞生长过程中协调蛋白质和脂质生物合成的调节途径的一部分。在本文中，我们讨论了越来越多的数据支持的潜在机制mTORC 1依赖性激活SREBP以及这种信号通路在癌症中的影响。
In recent years several reports have linked mTORC1 (mammalian target of rapamycin complex 1) to lipogenesis via the SREBPs (sterol-regulatory-element-binding proteins). SREBPs regulate the expression of genes encoding enzymes required for fatty acid and cholesterol biosynthesis. Lipid metabolism is perturbed in some diseases and SREBP target genes, such as FASN (fatty acid synthase), have been shown to be up-regulated in some cancers. We have previously shown that mTORC1 plays a role in SREBP activation and Akt/PKB (protein kinase B)-dependent de novo lipogenesis. Our findings suggest that mTORC1 plays a crucial role in the activation of SREBP and that the activation of lipid biosynthesis through the induction of SREBP could be part of a regulatory pathway that co-ordinates protein and lipid biosynthesis during cell growth. In the present paper, we discuss the increasing amount of data supporting the potential mechanisms of mTORC1-dependent activation of SREBP as well as the implications of this signalling pathway in cancer.