Disease Specific Mortality in Patients with Low Risk Bladder Cancer and the Impact of Cystoscopic Surveillance
Disease Specific Mortality in Patients with Low Risk Bladder Cancer and the Impact of Cystoscopic Surveillance
复制标题
DOI：
10.1016/j.juro.2012.09.084
复制
发表时间：
2013-03-01
影响因子：
6.6
通讯作者：
Catto, James W. F.
中科院分区：
文献类型：
--
作者：
Linton, Kate D.;Rosario, Derek J.;Catto, James W. F.
目的：我们确定了原发性低风险非侵袭性（G1 pTa）膀胱癌患者的疾病特异性死亡率的风险，并将其与年龄和性别匹配的一般人群的疾病特异性死亡率进行了比较。材料和方法：我们确定了所有原发性低风险癌症患者在我们的机构。我们排除了那些有不良病理特征的患者，然后匹配组织病理学、药房、医院发作和癌症登记记录。我们回顾了随后发生肌肉浸润（进展）或疾病特异性死亡的患者的病例记录。患者接受切除术后监测和使用标准方案治疗。国家和地区的疾病特异性死亡率从适当的data.Results计算：共699例患者符合研究纳入标准。中位随访时间为61个月（IQR 24-105）。17例患者（2.4%）死于膀胱癌，包括14例进展为肌肉浸润的患者中的13例和19例进展为高级别非肌肉浸润性疾病的患者中的4例。在考克斯回归分析中，初次切除标本中低度异型增生和肿瘤重量与疾病特异性死亡率相关（p
Purpose: We determined the risk of disease specific mortality in patients with primary, low risk, noninvasive (G1pTa) bladder cancer and compared it to disease specific mortality in age and gender matched general populations.Materials and Methods: We identified all patients with primary low risk cancer at our institution. We excluded those with adverse pathological features and then matched histopathology, pharmacy, hospital episode and Cancer Registry records. We reviewed case notes on patients with subsequent muscle invasion (progression) or disease specific mortality. Patients underwent post-resection surveillance and treatment using standard regimens. National and regional disease specific mortality rates were calculated from appropriate data.Results: A total of 699 patients met study inclusion criteria. Median followup was 61 months (IQR 24-105). Of the patients 17 (2.4%) died of bladder cancer, including 13 of 14 with progression to muscle invasion and 4 of 19 with grade progression to high grade, nonmuscle invasive disease. On Cox regression analyses low grade dysplasia in the initial resection specimen and tumor weight were associated with disease specific mortality (p