A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9-16 Carbon Atoms as Potential Ligands of the Receptor.
A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9-16 Carbon Atoms as Potential Ligands of the Receptor.
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从含有醛部分的食品中的风味挥发物中寻找 CD36 配体：鉴定具有 9-16 个碳原子的饱和脂肪醛作为受体的潜在配体。
DOI：
10.1021/acs.jafc.7b01890
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发表时间：
2017
影响因子：
6.1
通讯作者：
Inoue K
中科院分区：
文献类型：
--
作者：
Tsuzuki S;Amitsuka T;Okahashi T;Kimoto Y;Inoue K
具有醛部分的挥发性化合物如（Z）-9-十八烯醛是分化簇36（CD 36）的潜在配体，分化簇36是最近已显示在哺乳动物嗅觉中起作用的跨膜受体。在这项研究中，通过使用人CD 36的肽模拟物进行测定，我们的目的是从人类食物中常见的含有单个醛基的挥发物中发现受体的其他配体。具有9-16个碳的直链饱和脂肪族醛表现出CD 36配体活性，尽管程度不同。值得注意的是，十三醛和十四醛的活性高于油酸的活性，油酸是测试的脂肪酸中最有效的配体。在脂肪醛以外的醛中，只有苯乙醛表现出较弱的活性。这些发现有助于我们认识食品中的风味挥发物与醛基的识别机制。
Volatile compounds with an aldehyde moiety such as (Z)-9-octadecenal are potential ligands for cluster of differentiation 36 (CD36), a transmembrane receptor that has recently been shown to play a role in mammalian olfaction. In this study, by performing an assay using a peptide mimic of human CD36, we aimed to discover additional ligands for the receptor from volatiles containing a single aldehyde group commonly found in human foods. Straight-chain, saturated aliphatic aldehydes with 9–16 carbons exhibited CD36 ligand activities, albeit to varying degrees. Notably, the activities of tridecanal and tetradecanal were higher than that of oleic acid, the most potent ligand among the fatty acids tested. Among the aldehydes other than aliphatic aldehydes, only phenylacetaldehyde showed a weak activity. These findings make a contribution to our knowledge of recognition mechanisms for flavor volatiles in foods with an aldehyde group.