Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis
Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis
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DOI：
10.1038/s41598-020-66671-w
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发表时间：
2020-06-22
影响因子：
4.6
通讯作者：
Olesen, Morten S.
中科院分区：
文献类型：
--
作者：
Andreasen, Laura;Bertelsen, Litten;Olesen, Morten S.
心房颤动（AF）传统上被认为是一种电心脏病。然而，遗传学研究表明，心脏的结构也起着重要作用。我们使用心脏磁共振（CMR）评估了房颤患者携带肌联蛋白截短变体（TTNtv）的功能和结构后果。将17例携带TTNtv的早发性AF病例与非AF对照和未携带TTNtv的早发性AF病例的重复队列1：1匹配，并进行CMR。心脏容积和左心房晚期钆增强（LA LGE），作为纤维化的代理，由一个不知情的操作员测量。结果：房颤伴TTNtv患者的左室射血分数（LVEF）较对照组显著降低（57 +/-4vs 64 +/-5%，P
Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 +/- 4 vs 64 +/- 5%, P