Metalloproteinase-2 and-9 in diabetic and nondiabetic subjects during acute coronary syndromes
Metalloproteinase-2 and-9 in diabetic and nondiabetic subjects during acute coronary syndromes
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DOI：
10.1080/10623320601177064
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发表时间：
2007-01-01
影响因子：
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通讯作者：
D'Angelo, Angela
中科院分区：
文献类型：
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作者：
Derosa, Giuseppe;Cicero, Arrigo F. G.;D'Angelo, Angela
作者推测，急性冠脉综合征(ACSS)患者存在基质金属蛋白酶(MMPs)-2、-9及其组织抑制物(TIMP)-1、-2的异常。检测糖尿病合并ACSS患者与非糖尿病ACSS患者血浆中基质金属蛋白酶-2、-9和TIMP-1、-2的水平。共有46名糖尿病患者和78名非糖尿病ACSS患者入选。测定体重指数(BMI)、糖化血红蛋白(HbA(1c))、空腹血糖(FPG)、空腹血浆胰岛素(FPI)、稳态模型评估指数(HOMA指数)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)、甘油三酯(TG)、脂蛋白(A)[Lp(A)]、纤溶酶原激活物抑制物-1(PAI-1)、同型半胱氨酸(HCT)、纤维蛋白原(Fg)、超敏C反应蛋白(hs-CRP)和血浆基质金属蛋白酶-2、基质金属蛋白酶-9、基质金属蛋白酶-1和基质金属蛋白酶-2水平。糖尿病合并ACSS组HbA(1c)、空腹血糖、空腹血糖、HOMA指数、舒张压、甘油三酯、Hct和Fg显著升高，而hs-CRP低于非糖尿病合并ACSS组。糖尿病合并ACSS患者的血浆MMP9、TIMP-1和TIMP-2水平高于非糖尿病ACSS患者。糖尿病合并ACSS患者血浆中MMP9、TIMP-1、TIMP-2水平升高，可能反映了糖尿病急性期细胞外基质代谢异常。
The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured: body mass index (BMI), glycosylated hemoglobin (HbA(1c)), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA(1c), FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event.