Clinical Sound Speed Measurement in Liver and Spleen in Vivo
Clinical Sound Speed Measurement in Liver and Spleen in Vivo
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体内肝脏和脾脏的临床声速测量
DOI：
10.1177/016173468700900401
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发表时间：
1987
影响因子：
2.3
通讯作者：
B. Doust
中科院分区：
文献类型：
--
作者：
C. Chen;D. Robinson;L. Wilson;K. Griffiths;A. Manoharan;B. Doust
本文描述了一种临床声速测量的实现，使用商用水路扫描仪或专门开发的双换能器实时扫描仪，每个传感器都与一台通用小型计算机连接，用于离线分析。它描述了从肝脏和脾脏获得合适的体内临床数据的检查技术。它开发了信号处理方法，以实现个体测量的临床信心。肝脏患者45例，脾脏患者46例。发现声速与肝脏和脾脏的纤维化含量密切相关，纤维化增加导致声速降低。讨论了不同病理条件下的声速。对正在接受治疗的患者进行顺序检查的临床结果被提出，并证明了疾病状态的成功监测。提出了声速测量在临床中的潜在作用。
The paper describes an implementation of clinical sound speed measurement using either a commercial water path scanner or a specially developed dual transducer real time scanner, each interfaced to a general purpose minicomputer for off-line analysis. It describes the examination technique to obtain suitable in vivo clinical data from the liver and the spleen. It develops signal processing methods to achieve clinical confidence in individual measurements. Forty-five liver patients and 46 spleen patients were examined. Sound speed was found to correlate closely with fibrosis content in both the liver and the spleen with an increase in fibrosis resulting in a decrease in sound speed. Sound speed in various pathological conditions are discussed. Clinical results of sequential examinations on patients under treatment are presented and successful monitoring of the disease status is demonstrated. The potential clinical role of sound speed measurement is suggested.