PET/CT using 68Ga-PSMA-617 versus 18F-fluorodeoxyglucose to differentiate low- and high-grade gliomas
PET/CT using 68Ga-PSMA-617 versus 18F-fluorodeoxyglucose to differentiate low- and high-grade gliomas
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DOI：
10.1111/jon.12856
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发表时间：
2021-05-22
影响因子：
2.4
通讯作者：
Wang, Jing
中科院分区：
文献类型：
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作者：
Liu, Daliang;Cheng, Guang;Wang, Jing
背景与目的 采用 Ga-68-PSMA-617 和 F-18-FDG 正电子发射断层扫描/计算机断层扫描 (PET/CT) 比较和表征高级别和低级别胶质瘤的代谢特征。方法 回顾性分析 30 例连续 2 d 接受 Ga-68-PSMA-617 和 F-18-FDG PET/CT 然后接受手术治疗的患者。所有肿瘤均通过组织学诊断。该报告包括 16 种高级别神经胶质瘤 (HGG) 和 14 种低级别神经胶质瘤 (LGG) 肿瘤。对整个肿瘤区域的标准摄取值（SUV）和靶标到非靶标（T/NT）进行定量研究。使用曲线下面积 (AUC) 和两种平均值的比较进行统计分析。结果 SUVmax 和 SUVmean 对于区分 HGG 和 LGG 最为有效（PSMA PET 的 AUC 分别为 0.96 和 0.94；FDG PET 的 AUC 分别为 0.79 和 0.74）。这些方法有效地区分了 HGG 和 LGG（PSMA PET：SUVmax，分别为 5.766 +/- 3.945 与 0.7364 +/- 0.5295，p < 0.0001；SUVmean，分别为 1.666 +/- 1.680 和 0.1514 +/- 0.1534，p < 0.0001）（FDG PET： SUVmax，11.67 +/- 3.639 和 9.118 +/- 6.612；SUVmean，5.648 +/- 2.114 和 4.435 +/- 2.872；p = 0.0083、0.0262。 Ga-68-PSMA-617和F-18-FDG的SUVmax和SUVmean的约登指数分别为0.82和0.79以及0.54和0.61。 T/NTmax有助于目视检查Ga-68-PSMA-617-PET图像（T/NTmax：II级为1.291+/-0.9553，III级为5.25+/-2.435，IV级为13.61+/-13.84）。 LGG与HGG之间以及LGG亚型之间T/NTmax存在显着差异。 结论 Ga-68-PSMA-617和F-18-FDG PET/CT可能有助于区分HGG和LGG，且Ga-68-PSMA-617 PET/CT在区分HGG和LGG方面优于(18)F-FDG。
Background and purpose To compare and characterize metabolic features of high- and low-grade glioma tumors using Ga-68-PSMA-617 and F-18-FDG positron emission tomography/computed tomography (PET/CT).Methods Thirty patients who underwent both Ga-68-PSMA-617 and F-18-FDG PET/CT over 2 consecutive days and then underwent surgical treatment were retrospectively identified. All tumors were diagnosed histologically. This report includes 16 high-grade glioma (HGG) and 14 low-grade glioma (LGG) tumors. Standard uptake value (SUV) and target to nontarget (T/NT) were quantitatively investigated through the entire tumor region. Statistical analyses were performed using area under the curve (AUC) and comparison of two means.Results SUVmax and SUVmean were the most effective (AUC, 0.96 and 0.94 for PSMA PET; AUC, 0.79 and 0.74 for FDG PET, respectively) for differentiating HGGs from LGGs. These methods distinguished between HGG and LGG effectively (PSMA PET: SUVmax, 5.766 +/- 3.945 vs. 0.7364 +/- 0.5295, p < 0.0001; SUVmean, 1.666 +/- 1.680 and 0.1514 +/- 0.1534, p < 0.0001, respectively) (FDG PET: SUVmax, 11.67 +/- 3.639 and 9.118 +/- 6.612; SUVmean, 5.648 +/- 2.114 and 4.435 +/- 2.872; p = 0.0083, 0.0262, respectively). The Youden index for SUVmax and SUVmean of Ga-68-PSMA-617 and F-18-FDG were 0.82 and 0.79 and 0.54 and 0.61, separately. T/NTmax was helpful for visual inspection of Ga-68-PSMA-617-PET images (T/NTmax: 1.291 +/- 0.9553 in grade II, 5.25 +/- 2.435 in grade III, and 13.61 +/- 13.84 in grade IV). T/NTmax differed significantly between LGG and HGG and between subtypes of LGG.Conclusion PET/CT with Ga-68-PSMA-617 and F-18-FDG may help distinguish between HGG and LGG, and Ga-68-PSMA-617 PET/CT is superior to(18)F-FDG in differentiating HGG and LGG.