WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.
WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.
复制标题
盘基网柄菌肌球蛋白重链激酶 C 的 WD 重复结构域在底物靶向和细胞定位中发挥作用。
DOI：
10.1128/ec.00242-09
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Steimle,PaulA
中科院分区：
文献类型：
--
作者：
Franklin,Atiya;Hyatt,Linzi;Chowdhury,Alyssa;Steimle,PaulA
盘基网柄菌中肌球蛋白II的分解受三种结构上相关的肌球蛋白重链激酶(肌球蛋白II重链激酶A[MHCK-A]、-B和-C)的调节。我们发现MHCK-C的WD重复结构域是独特的，因为它介导底物靶向和亚细胞定位，揭示了一个不同于其他MHCK的调控靶点。
Myosin II disassembly in Dictyostelium discoideum is regulated by three structurally related myosin heavy chain kinases (myosin II heavy chain kinase A [MHCK-A], -B, and -C). We show that the WD repeat domain of MHCK-C is unique in that it mediates both substrate targeting and subcellular localization, revealing a target for regulation that is distinct from those of the other MHCKs.