Arrested development: suppression of NK cell function in the tumor microenvironment.
Arrested development: suppression of NK cell function in the tumor microenvironment.
复制标题
DOI：
10.1002/cti2.1238
复制
发表时间：
2021
影响因子：
5.8
通讯作者：
O'Sullivan TE
中科院分区：
文献类型：
--
作者：
Riggan L;Shah S;O'Sullivan TE
自然杀伤细胞（NK）是一种具有细胞毒性的先天淋巴细胞，可以防止病毒感染和肿瘤转移。尽管NK细胞具有杀死广泛的病毒感染、应激和转化细胞的固有能力，但在许多晚期实体人类癌症中经常观察到少量功能失调的NK细胞。在这里，我们回顾了影响实体瘤肿瘤微环境（TME）中次优成熟NK细胞募集和功能的潜在机制。我们进一步强调了目前旨在规避NK细胞功能障碍的免疫治疗方法，并讨论了下一代策略，通过靶向调节TME中NK细胞功能的内在和外在检查点来增强过继NK细胞治疗。了解在TME中驱动NK细胞功能障碍的机制将导致新的免疫治疗方法与癌症作斗争。在这篇综述中，我们总结了目前的文献分析NK细胞在实体肿瘤微环境中促进功能失调反应的内在和外在机制。我们批判性地分析了当前的文献，并提出了基于NK细胞的癌症免疫治疗的开放性问题和新方向。
Natural killer (NK) cells are cytotoxic innate lymphocytes that protect against viral infection and tumor metastasis. Despite their inherent ability to kill a broad range of virally infected, stressed and transformed cells, low numbers of dysfunctional NK cells are often observed in many advanced solid human cancers. Here, we review the potential mechanisms that influence suboptimal mature NK cell recruitment and function in the tumor microenvironment (TME) of solid tumors. We further highlight current immunotherapy approaches aimed to circumvent NK cell dysfunction and discuss next‐generation strategies to enhance adoptive NK cell therapy through targeting intrinsic and extrinsic checkpoints the regulate NK cell functionality in the TME. Understanding the mechanisms that drive NK cell dysfunction in the TME will lead to novel immunotherapeutic approaches in the fight against cancer. In this review, we provide a summary of the current literature profiling intrinsic and extrinsic mechanisms of NK cells that promote dysfunctional responses in solid tumor microenvironments. We critically analyse the current literature and propose open questions as well as new directions for NK‐cell‐based immunotherapies in cancer.
登录
查看更多内容
影响因子：
11.2
作者：
Cichocki F;Valamehr B;Bjordahl R;Zhang B;Rezner B;Rogers P;Gaidarova S;Moreno S;Tuininga K;Dougherty P;McCullar V;Howard P;Sarhan D;Taras E;Schlums H;Abbot S;Shoemaker D;Bryceson YT;Blazar BR;Wolchko S;Cooley S;Miller JS
通讯作者：
Miller JS
影响因子：
4.4
作者：
Carrega, Paolo;Bonaccorsi, Irene;Ferlazzo, Guido
通讯作者：
Ferlazzo, Guido
影响因子：
15.9
作者：
Crane, Courtney A.;Han, Seunggu J.;Parsa, Andrew T.
通讯作者：
Parsa, Andrew T.
影响因子：
3.7
作者：
Charych D;Khalili S;Dixit V;Kirk P;Chang T;Langowski J;Rubas W;Doberstein SK;Eldon M;Hoch U;Zalevsky J
通讯作者：
Zalevsky J
影响因子：
30.5
作者：
Bald T;Krummel MF;Smyth MJ;Barry KC
通讯作者：
Barry KC