Brain structure changes visualized in early- and late-onset blind subjects.
Brain structure changes visualized in early- and late-onset blind subjects.
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DOI：
10.1016/j.neuroimage.2009.07.048
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Lepore, Natasha;Voss, Patrice;Lepore, Franco;Chou, Yi-Yu;Fortin, Madeleine;Gougoux, Frederic;Lee, Agatha D.;Brun, Caroline;Lassonde, Maryse;Madsen, Sarah K.;Toga, Arthur W.;Thompson, Paul M.
We examine 3D patterns of volume differences in the brain associated with blindness, in subjects grouped according to early and late onset. Using tensor-based morphometry, we map volume reductions and gains in 16 early-onset (EB) and 16 late-onset (LB) blind adults (onset <5 and >14 years old, respectively) relative to 16 matched sighted controls. Each subject’s structural MRI was fluidly registered to a common template. Anatomical differences between groups were mapped based on statistical analysis of the resulting deformation fields revealing profound deficits in primary and secondary visual cortices for both blind groups. Regions outside the occipital lobe showed significant hypertrophy, suggesting widespread compensatory adaptations. EBs but not LBs showed deficits in the splenium and hypertrophy in the isthmus. Gains in the isthmus and non-occipital white matter were more widespread in the EBs. These differences may reflect regional alterations in late neurodevelopmental processes, such as myelination, that continue into adulthood.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
3.7
作者：
Collignon, Olivier;Lassonde, Maryse;Veraart, Claude
通讯作者：
Veraart, Claude
影响因子：
64.8
作者：
Cohen, LG;Celnik, P;Hallett, M
通讯作者：
Hallett, M
影响因子：
5.7
作者：
Chung, MK;Worsley, KJ;Evanst, AC
通讯作者：
Evanst, AC
影响因子：
14.5
作者：
Fortin, Madeleine;Voss, Patrice;Lepore, Franco
通讯作者：
Lepore, Franco