Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
复制标题
DOI：
10.1503/cmaj.091823
复制
发表时间：
2010-03-09
影响因子：
14.6
通讯作者：
Pelletier, Louise
中科院分区：
文献类型：
--
作者：
Campbell, Alexia;Rodin, Rachel;Pelletier, Louise
背景资料：我们描述了疾病的特点和结果，包括入院重症监护病房（ICU）和死亡的危险因素，在加拿大的所有患者入院与大流行（H1N1）流感在大流行的前五个月。方法：我们获得了所有实验室确诊的H1N1流感大流行住院患者的数据。加拿大公共卫生署于4月26日至9月27日收到流感报告。2009年26日。我们比较了住院患者谁有非严重的疾病与那些谁有严重的疾病，入院ICU或death.Results：共1479例患者入院确诊的大流行性流感（H1N1）在研究期间。其中，1171例（79.2%）无严重结局，236例（16.0%）入住ICU并存活，72例（4.9%）死亡。所有患者的中位年龄为23岁，非严重结局的患者为18岁，入住ICU存活的患者为34岁，死亡的患者为51岁。在那些有基础疾病和20岁及以上的人中，严重结局的风险升高。症状发作和入院之间的中位时间延迟一天，死亡风险增加5.5%。严重后果的风险在5个月期间保持相对恒定。解释：在加拿大大流行的前5个月，实验室确诊的大流行性（H1N1）流感入院的人群发病率较低。重度结局的风险与存在一种或多种基础疾病、年龄≥ 20岁和延迟入院相关。
Background: We describe the disease characteristics and outcomes, including risk factors for admission to intensive care unit (ICU) and death, of all patients in Canada admitted to hospital with pandemic (H1N1) influenza during the first five months of the pandemic.Methods: We obtained data for all patients admitted to hospital with laboratory-confirmed pandemic (H1N1) influenza reported to the Public Health Agency of Canada from Apr. 26 to Sept. 26, 2009. We compared inpatients who had nonsevere disease with those who had severe disease, as indicated by admission to ICU or death.Results: A total of 1479 patients were admitted to hospital with confirmed pandemic (H1N1) influenza during the study period. Of these, 1171 (79.2%) did not have a severe outcome, 236 (16.0%) were admitted to ICU and survived, and 72 (4.9%) died. The median age was 23 years for all of the patients, 18 years for those with a nonsevere outcome, 34 years for those admitted to ICU who survived and 51 years for those who died. The risk of a severe outcome was elevated among those who had an underlying medical condition and those 20 years of age and older. A delay of one day in the median time between the onset of symptoms and admission to hospital increased the risk of death by 5.5%. The risk of a severe outcome remained relatively constant over the five-month period.Interpretation: The population-based incidence of admission to hospital with laboratory-confirmed pandemic (H1N1) influenza was low in the first five months of the pandemic in Canada. The risk of a severe outcome was associated with the presence of one or more underlying medical conditions, age of 20 years or more and a delay in hospital admission.