AMERICAN ACADEMY OF EMERGENCY MEDICINE POSITION STATEMENT: SAFETY OF DROPERIDOL USE IN THE EMERGENCY DEPARTMENT
AMERICAN ACADEMY OF EMERGENCY MEDICINE POSITION STATEMENT: SAFETY OF DROPERIDOL USE IN THE EMERGENCY DEPARTMENT
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DOI：
10.1016/j.jemermed.2014.12.024
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发表时间：
2015-07-01
影响因子：
1.5
通讯作者：
DeMers, Gerard
中科院分区：
文献类型：
--
作者：
Perkins, Jack;Ho, Jeffrey D.;DeMers, Gerard
背景：氟哌啶醇（Inapsine (R), Glaxosmithkline, Brent， UK）是一种用于急诊医学实践的丁苯酮，有多种用途。QT间期延长是这类药物的一个众所周知的副作用。值得注意的是，QT间期延长与多种药物类别有关，而哌啶醇在易感个体中以剂量依赖的方式增加QT间期。本文献检索的主要目的是确定报道的氟哌啶醇在急诊科患者管理中的安全性问题。方法：检索1995年1月至2014年1月MEDLINE文献，检索以盐酸哌啶醇/茚三酮为关键词的英文人类研究文献。指南声明和非系统评价被排除在外。然后对确定的研究进行结构化审查，从而对结果进行评估。结果：筛选到有关氟哌啶醇的文献542篇，对35篇合适的文献进行了严格的详细审查，并给出了推荐。结论：氟哌啶醇是一种安全有效的治疗恶心、头痛、躁动的药物。文献检索不支持强制心电图或遥测监测剂量< d2.5 mg肌肉或静脉注射。肌注剂量高达10毫克的氟哌啶醇似乎与用于镇静激动患者的其他药物一样安全有效。Elsevier Inc.出版。
Background: Droperidol (Inapsine (R), Glaxosmithkline, Brent, UK) is a butyrophenone used in emergency medicine practice for a variety of uses. QT prolongation is a well-known adverse effect of this class of medications. Of importance to note, QT prolongation is noted with multiple medication classes, and droperidol increases QT interval in a dose-dependent fashion among susceptible individuals. The primary goal of this literature search was to determine the reported safety issues of droperidol in emergency department management of patients. Methods: A MEDLINE literature search was conducted from January 1995 to January 2014 and limited to human studies written in English for articles with keywords of droperidol/Inapsine. Guideline statements and nonsystematic reviews were excluded. Studies identified then underwent a structured review from which results could be evaluated. Results: There were 542 papers on droperidol screened, and 35 appropriate articles were rigorously reviewed in detail and recommendations given. Conclusion: Droperidol is an effective and safe medication in the treatment of nausea, headache, and agitation. The literature search did not support mandating an electrocardiogram or telemetry monitoring for doses < d2.5 mg given either intramuscularly or intravenously. Intramuscular doses of up to 10 mg of droperidol seem to be as safe and as effective as other medications used for sedation of agitated patients. Published by Elsevier Inc.