Effects of propranolol or paracetamol on lidocaine concentrations in serum and tissues
Effects of propranolol or paracetamol on lidocaine concentrations in serum and tissues
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DOI：
10.1053/joms.2003.50090
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发表时间：
2003-05-01
影响因子：
1.9
通讯作者：
Tesseromatis, C
中科院分区：
文献类型：
--
作者：
Saranteas, B;Mourouzis, C;Tesseromatis, C
目的：研究扑热息痛和心得安给药后利多卡因的相互作用。材料和方法：A组大鼠咬肌内注入冷利多卡因和C-14利多卡因混合液。B组大鼠口服利多卡因和扑热息痛7.5 mg/kg，C组肌肉注射利多卡因和心得安1.5 mg/kg。连续给药5次。测定血清中这些药物的浓度，并测定利多卡因在肝脏和下颌骨组织中的总浓度和蛋白结合率。结果：扑热息痛和心得安给药后，大鼠血清中利多卡因浓度均显著升高。结论：利多卡因与扑热息痛或普萘洛尔合用可干扰药物代谢过程，产生药动学相互作用，对临床确定正确剂量利多卡因有重要意义。(C)2003年美国口腔和颌面外科医生协会。
Purpose: The goal of this study was to determine the interaction of lidocaine after paracetamol or propranolol administration.Materials and Methods: Group A rats received a mixture of cold lidocaine and C-14 lidocaine into the masseter muscle. Group B rats received lidocaine and paracetamol 7.5 mg/kg orally, whereas group C received lidocaine intramuscularly and propranolol 1.5 mg/kg orally. Five consecutive doses were administered. The levels of these drugs were estimated in serum and the total concentration and the percent protein binding of lidocaine in tissues (liver and mandible) were determined. The rats were killed 2 hours after the last dose.Results: The results suggest that lidocaine concentrations in serum were significantly increased after either paracetamol or propranolol administration. Additionally, the combined therapy of propranolol and lidocaine resulted in a significant decrease in the total concentration and the percent protein binding of lidocaine in tissues.Conclusions: The coadministration of lidocaine with paracetamol or propranolol interferes with the metabolic profile, resulting in pharmacokinetic interactions that may be significant for the determination of the correct dose of lidocaine in clinical applications. (C) 2003 American Association of Oral and Maxillofacial Surgeons.