OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH EARLY-ONSET DRUSEN
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早发性玻璃疣相关脉络膜新生血管的光学相干断层扫描血管造影研究
DOI：
10.1097/icb.0000000000000856
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发表时间：
2019
影响因子：
--
通讯作者：
Obata Ryo
中科院分区：
文献类型：
--
作者：
Terao Ryo;Matsuda Aya;Ogawa Asako;Shimizu Kimiko;Azuma Keiko;Inoue Tatsuya;Obata Ryo
目的：报告3例经光学相干断层扫描血管造影（OCTA）证实的伴有早发性玻璃疣的脉络膜新生血管（CNV）。眼底检查，荧光素血管造影，吲哚菁绿色血管造影，OCTA，和其他多模态imaging performed.Results：例1涉及一个47岁的女性谁提出了突然单侧斜视。她以前没有全身性疾病。眼底镜检查及萤光素血管摄影显示双侧大的胶样玻璃疣并伴有单侧轻度视网膜下出血。吲哚菁绿色血管造影显示CNV，尽管荧光素血管造影不清楚。光学相干断层扫描血管造影也显示视网膜色素上皮下的互连CNV。病例2涉及一名40岁女性膜增生性肾小球肾炎3型谁提出了单侧斜视。在萤光素血管摄影上，双眼均可见继发于膜增生性肾小球肾炎的表皮玻璃疣。OCTA和吲哚菁绿色血管造影显示了相互连接的血管网，表明患眼存在1型CNV。病例3涉及一名47岁男性，无任何病史或家族史。双眼均以大胶质玻璃疣为主，伴有表皮玻璃疣。结论：本组早发性玻璃膜疣均为1型CNV，吲哚菁绿绿色血管造影或OCTA均可检出1型CNV。光学相干断层扫描血管造影术有可能帮助非侵入性诊断CNV的情况下，EOD。
Purpose:To report three middle-aged cases with choroidal neovascularization (CNV) associated with early-onset drusen documented with optical coherence tomography angiography (OCTA).Methods:Three patients with bilateral early-onset drusen were referred to our hospital. Fundus examination, fluorescein angiography, indocyanine green angiography, OCTA, and other multimodal imaging were performed.Results:Case 1 involved a 47-year-old woman who presented with sudden unilateral anorthopia. She had no previous systemic pathologies. Funduscopic examination and fluorescein angiography revealed bilateral large colloid drusen accompanied by unilateral mild subretinal hemorrhage. Indocyanine green angiography revealed CNV, although it was unclear in fluorescein angiography. Optical coherence tomography angiography also showed interconnecting CNV beneath the retinal pigment epithelium. Case 2 involved a 40-year-old woman with membranoproliferative glomerulonephritis Type 3 who presented with unilateral anorthopia. On fluorescein angiography, cuticular drusen secondary to membranoproliferative glomerulonephritis were seen in both eyes. An interconnecting vascular network was revealed with OCTA and indocyanine green angiography indicating Type 1 CNV in the affected eye. Case 3 involved a 47-year-old man without any medical or family history. Predominant large colloid drusen associated with cuticular drusen were seen in both eyes. Unilateral mild serosanguinous changes were accompanied in the macula, where Type 1 CNV was detected with OCTA.Conclusion:All our cases with early-onset drusen showed Type 1 CNV that was detected by indocyanine green angiography or OCTA. Optical coherence tomography angiography has a potential to help noninvasively diagnose CNV in the cases of EOD.