Mnemonic Training Reshapes Brain Networks to Support Superior Memory.
Mnemonic Training Reshapes Brain Networks to Support Superior Memory.
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DOI：
10.1016/j.neuron.2017.02.003
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发表时间：
2017-03-08
期刊：
影响因子：
16.2
通讯作者：
Greicius MD
中科院分区：
文献类型：
--
作者：
Dresler M;Shirer WR;Konrad BN;Müller NCJ;Wagner IC;Fernández G;Czisch M;Greicius MD
一般人群的记忆技能差异很大，但人们对支持卓越记忆表现的大脑特征知之甚少。在这里，我们评估了 23 位世界上最成功的记忆运动员的功能性大脑网络组织，并通过功能磁共振成像在无任务静息状态基线和主动记忆编码期间进行匹配控制。我们证明，在一组幼稚的对照组中，六周的助记训练引起的功能连接变化与区分运动员和对照组的网络组织相关。在休息期间，这种效应主要是由视觉、内侧颞叶和默认模式网络之间的连接而不是内部的连接驱动的，而在任务期间，它是由这些网络内的连接驱动的。与记忆运动员连接模式的相似性预测训练后长达 4 个月的记忆力改善。总之，助记训练驱动的是分布式而非区域性的变化，重组大脑的功能网络组织以实现卓越的记忆性能。
Memory skills strongly differ across the general population, however little is known about the brain characteristics supporting superior memory performance. Here, we assess functional brain network organization of 23 of the world’s most successful memory athletes and matched controls by fMRI during both task-free resting state baseline and active memory encoding. We demonstrate that in a group of naïve controls, functional connectivity changes induced by six weeks of mnemonic training were correlated with the network organization that distinguishes athletes from controls. During rest, this effect was mainly driven by connections between rather than within the visual, medial temporal lobe and default mode networks, whereas during task it was driven by connectivity within these networks. Similarity with memory athlete connectivity patterns predicted memory improvements up to 4 months after training. In conclusion, mnemonic training drives distributed rather than regional changes, reorganizing the brain’s functional network organization to enable superior memory performance.