Safe and Efficient Ritter Reactions in Flow
Safe and Efficient Ritter Reactions in Flow
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DOI：
10.1055/s-0030-1259075
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发表时间：
2010-12-01
期刊：
影响因子：
2
通讯作者：
Wirth, Thomas
中科院分区：
文献类型：
--
作者：
Brandt, Johan C.;Elmore, Simon C.;Wirth, Thomas
高效的混合、温度控制和较小的环境暴露使得在微流体装置中进行的反应的性能优于传统烧瓶中的批量式反应。 Ritter 反应针对流动条件进行了优化，从而缩短了反应时间并提高了产率，并且在安全性、生产率和对底物功能的耐受性方面也更加可行。
Efficient mixing, temperature control and small environmental exposures allow reactions carried out in microfluidic devices to perform superior to their batch-type counterparts in conventional flasks. The Ritter reaction has been optimised for flow conditions leading to short reaction times and higher yields and also is more feasible with regards to safety, productivity and tolerance towards substrate functionalities.