Movement disorders associated with antiseizure medications: A systematic review.

Movement disorders associated with antiseizure medications: A systematic review.
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DOI:
10.1016/j.yebeh.2022.108693
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发表时间:
2022-06
影响因子:
2.6
通讯作者:
Taraschenko, Olga
Taraschenko, Olga
中科院分区:
医学3区
文献类型:
--
作者:
Zhou, Daniel J.;Pavuluri, Spriha;Snehal, Isha;Schmidt, Cynthia M.;Situ-Kcomt, Miguel;Taraschenko, Olga

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与抗癫痫药物(ASM)的使用有关的新的发作运动障碍的报道已经很频繁。各种ASM的特定运动表现的频率及其符号学的频谱尚未得到很好的描述。我们对文献进行了系统的综述,并检索了CINAHL、Cochrane图书馆、EMBASE、MEDLINE、SqucINFO和Scope us,从最初到2021年4月。我们使用传统的运动障碍术语汇编了目前所有可用的ASM的数据。在检索确定的5123篇稿件中,有437篇符合纳入标准。最多的异常运动报告与苯巴比妥、丙戊酸、乳糖胺和帕金森有关,主要包括震颤和共济失调。对所有药物的大多数干预尝试是停用违规药物或减少剂量,这导致大多数患者的症状得到缓解。熟悉以前遇到的与特定ASM有关的运动障碍现象学有助于及早认识到不良影响并及时采取有针对性的干预措施。
New onset movement disorders have been frequently reported in association with the use of antiseizure medications (ASMs). The frequency of specific motor manifestations and the spectrum of their semiology for various ASMs have not been well characterized. We carried out a systematic review of literature and conducted a search on CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, and Scopus from inception to April 2021. We compiled the data for all currently available ASMs using the conventional terminology of movement disorders. Among 5123 manuscripts identified by the search, 437 met the inclusion criteria. The largest number of reports of abnormal movements were in association with phenobarbital, valproic acid, lacosamide, and perampanel, and predominantly included tremor and ataxia. The majority of attempted interventions for all agents were discontinuation of the offending drug or dose reduction which led to the resolution of symptoms in most patients. Familiarity with the movement disorder phenomenology previously encountered in relation with specific ASMs facilitates early recognition of adverse effects and timely institution of targeted interventions.
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