Lymphatics in Idiopathic Pulmonary Fibrosis: New Insights into an Old Disease
Lymphatics in Idiopathic Pulmonary Fibrosis: New Insights into an Old Disease
复制标题
DOI：
10.1089/lrb.2009.0014
复制
发表时间：
2009-01-01
影响因子：
1.4
通讯作者：
Moss, Joel
中科院分区：
文献类型：
--
作者：
El-Chemaly, Souheil;Pacheco-Rodriguez, Gustavo;Moss, Joel
淋巴管系统在组织稳态和免疫监视中起着关键作用。越来越多的证据表明淋巴循环和新形成的淋巴管在肺部疾病的发病机制中起作用。特发性肺纤维化（IPF）是一种慢性、进行性、使人衰弱的肺部疾病。在IPF中，肺实质发生广泛重塑。本文综述了目前对IPF发病机制的认识和理解，以及淋巴管生成参与肺损伤和修复以及导致淋巴管形成的分子和细胞途径的最新证据。
The lymphatic vasculature plays a key role in tissue homeostasis and immune surveillance. There is mounting evidence of a role for the lymphatic circulation and for newly formed lymphatic vessels in the pathogenesis of lung disease. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, debilitating lung disease. In IPF, the lung parenchyma undergoes extensive remodeling. This review focuses on the current knowledge and understanding of the pathogenesis of IPF, and recent evidence of the involvement of lymphangiogenesis in lung injury and repair and the molecular and cellular pathways leading to the development of lymphatic vasculature.