ANTIGENIC RELATIONSHIPS AMONG SIMBU SEROGROUP (BUNYAVIRIDAE) VIRUSES
ANTIGENIC RELATIONSHIPS AMONG SIMBU SEROGROUP (BUNYAVIRIDAE) VIRUSES
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DOI：
10.4269/ajtmh.1981.30.1307
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
CALISHER, CH
中科院分区：
文献类型：
--
作者：
KINNEY, RM;CALISHER, CH
Simbu 血清群的 24 种布尼亚病毒之间的抗原关系通过补体结合 (CF)、血清稀释-空斑减少中和 (N) 以及可能的情况下血凝抑制 (HI) 测试来确定。通过CF，在该血清群中鉴定出密切相关的病毒的3种不同复合体。诺拉病毒和蒂米里病毒与该血清群的其他成员关系不大，可能代表另外两种复合体。 [非洲绿猴肾] Vero 细胞中的 N 测试表明，单个病毒通常可以轻松区分。通过 CF 或 N 无法区分艾诺病毒和凯卡鲁病毒。七种病毒表现出血凝活性，并且通过 HI 确定这些病毒之间的抗原关系与通过 N 测试建立的抗原关系相似。提出了基于 CF 和 N 测试结果的 Simbu 血清群病毒的分类方案。
Antigenic relationships among 24 bunyaviruses of the Simbu serogroup were determined by complement fixation (CF), serum dilution-plaque reduction neutralization (N) and, where possible, hemagglutination inhibition (HI) tests. By CF, 3 distinct complexes of closely related viruses were identified within the serogroup. Nola and Thimiri viruses, which showed little relationship with other members of the serogroup, may represent 2 additional complexes. N tests in [African green monkey kidney] Vero cells showed that individual viruses generally were distinguishable with little difficulty. Aino and Kaikalur viruses were indistinguishable by CF or N. Seven viruses showed hemagglutination activity, and antigenic relationships among these viruses by HI paralleled those established by N tests. A classification scheme, based on both CF and N test results, for the viruses of the Simbu serogroup is proposed.