Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate.
Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate.
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内分泌激活模拟了产前应激对灵长类婴儿神经运动发育的不利影响。
DOI：
10.1002/dev.420250604
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发表时间：
1992
影响因子：
2.2
通讯作者：
Lubach,GR
中科院分区：
文献类型：
--
作者：
Schneider,ML;Coe,CL;Lubach,GR
将妊娠雌性恒河猴暴露于促肾上腺皮质激素（ACTH）2周，以确定其是否会以类似于心理应激后观察到的方式影响其胎儿的早期神经运动发育。在出生后的第一个月内，婴儿进行了两次测试，修改了Brazelton新生儿行为评估量表。与对照组相比，ACTH治疗妊娠的婴儿表现出运动协调和肌肉紧张性的早期损伤以及较短的注意力持续时间。此外，在气质评定量表上，ACTH条件下的婴儿更易怒，难以安慰。这些发现表明，怀孕期间内分泌激活的限定时期可能对婴儿神经行为发育产生不利影响，如产前压力。© 1992 Wiley & Sons. Inc.
Pregnant female rhesus monkeys were exposed to a 2‐week period of adrenocorticotropic hormone (ACTH) to determine whether it would affect the early neuromotor development of their fetuses in a manner similar to that observed after psychological stressors. During the first month after birth, infants were tested on two occasions with a modification of the Brazelton Newborn Behavioral Assessment Scale. Infants derived from ACTH‐treated pregnancies showed early impairments in motor coordination and muscle tonicity and shorter attention spans as compared to controls. In addition, on a temperament rating scale, infants from the ACTH condition were more irritable and difficult to console. These findings indicate that a delimited period of endocrine activation during pregnancy can have an adverse effect on infant neurobehavioral development, like that of prenatal stress. © 1992 Wiley & sons. Inc.