SEROEPIDEMIOLOGICAL STUDY OF RELATIONSHIPS BETWEEN EPSTEIN-BARR VIRUS AND RHEUMATOID-ARTHRITIS
SEROEPIDEMIOLOGICAL STUDY OF RELATIONSHIPS BETWEEN EPSTEIN-BARR VIRUS AND RHEUMATOID-ARTHRITIS
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DOI：
10.1172/jci110083
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发表时间：
1981-01-01
影响因子：
15.9
通讯作者：
TAN, EM
中科院分区：
文献类型：
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作者：
FERRELL, PB;AITCHESON, CT;TAN, EM
为探讨EB病毒（Epstein-Barr virus，EBV）与类风湿关节炎（rheumatoid arthritis，RA）的关系，检测了RA患者和正常人血清中抗RA相关核抗原（anti-RANA）和其它3种EBV相关抗原的抗体。研究组包括89例确诊或典型RA患者，平均年龄56岁，男性/女性比例47：42; 53例正常和骨关节炎对照，平均年龄51岁，男性/女性比例25：28。检测病毒衣壳抗原（抗VCA）、早期抗原（抗EA）和EBV相关核抗原（抗EBNA）抗体。在71%的RA患者中检测到抗RANA，但仅在6%的对照组中检测到。抗VCA滴度升高（> 1：160）在RA患者中比对照组更常见，分别为31%和15%。抗VCA的几何平均滴度在RA组中显著更高，133比58。抗EA存在于53%的RA患者中，但仅19%的对照组。抗EA抗体滴度升高（> 1：20）的RA患者占26%，而对照组仅占7%。抗EA抗体的表征显示，RA患者主要与弥漫性成分反应;大多数对照与EA复合物的限制性成分反应。抗EBNA抗体的频率、分布和几何平均滴度在两组之间无显著差异。相关性分析显示RA组抗VCA与抗EA、抗RANA与抗EBNA之间有高度显著性相关。这些数据与RA患者具有比对照组更活跃的EBV感染或其对这种感染因子的免疫应答调节改变的解释是一致的。
To elucidate the relationship between Epstein-Barr virus (EBV) and rheumatoid arthritis (RA), antibodies to RA-associated nuclear antigen (anti-RANA) and 3 other EBV-related antigens in the sera of RA patients and controls were measured. Study groups consisted of 89 patients with definite or classical RA, mean age 56, male/female ratio 47:42; and 53 normal and osteoarthritis controls, mean age 51, male/female ratio 25:28. Antibodies to viral capsid antigen (anti-VCA), early antigen (anti-EA) and EBV-associated nuclear antigen (anti-EBNA) were measured. Anti-RANA was detected in 71% of RA patients but in only 6% of controls. Elevated anti-VCA titers (> 1:160) were more common in RA patients than controls, 31% compared with 15%. The geometric mean titer of anti-VCA was significantly higher in the RA group, 133 compared with 58. Anti-EA was present in 53% of RA patients but only 19% of controls. Anti-EA in elevated titers (> 1:20) was present in 26% of RA patients but only 7% of controls. Characterization of the anti-EA antibodies revealed that the RA patients reacted primarily with the diffuse component; the majority of the controls reacted with the restricted component of the EA complex. The frequencies, distributions and geometric mean titers of anti-EBNA were not significantly different between the 2 groups. Correlative analysis of these antibodies showed highly significant relationships between anti-VCA and anti-EA and anti-RANA and anti-EBNA in the RA group. These data are compatible with the interpretation that RA patients have either more active EBV infections than controls or an altered regulation of their immune response to this infectious agent.