DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS
DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS
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DOI：
10.1126/science.2315699
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发表时间：
1990-03-16
期刊：
影响因子：
56.9
通讯作者：
SAUER, RT
中科院分区：
文献类型：
--
作者：
BOWIE, JU;REIDHAAROLSON, JF;SAUER, RT
氨基酸序列编码的信息决定了蛋白质的形状和功能。这个信息是高度简并的，因为许多不同的序列可以编码本质上具有相同结构和活性的蛋白质。比较具有相似信息的不同序列可以揭示代码的关键特征，并提高对蛋白质如何折叠及其如何发挥功能的理解。
An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.