Low frequency of microsatellite instability in hereditary prostate cancer
Low frequency of microsatellite instability in hereditary prostate cancer
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DOI：
10.1046/j.1464-410x.2001.00104.x
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发表时间：
2001-03-01
影响因子：
4.5
通讯作者：
Grönberg, H
中科院分区：
文献类型：
--
作者：
Åhman, AK;Jonsson, BA;Grönberg, H
目的探讨遗传性前列腺癌（HPC）家系中是否存在广泛的微卫星不稳定性（MSI），对来自35个HPC家系的80名瑞典男性84例前列腺肿瘤患者进行微卫星标记位点BAT-25、BAT-26、BAT-34 C4、BAT-34 C5、BAT-34 C6、BAT-34 C7、BAT-34 C8、BAT-D2 S123和D17 S250。结果在5个不同家系的个体中检测到MSI。三个肿瘤（4%）是不稳定的，在两个以上的MSI位点，因此分类高频MSI（MSI-H）根据以前的定义，有趣的是，两个MSI-H肿瘤的患者在家庭与HPC和家族性结肠cancer.Conclusions广泛的MSI是一个罕见的事件，遗传性前列腺癌，表明有缺陷的DNA错配修复是不是一个重要的元素在HPC的成因。
Objective To investigate whether there is widespread microsatellite instability (MSI) in families with hereditary prostate cancer (HPC).Patients and methods Eighty-four prostate tumours from 80 Swedish men in 35 families with HPC were screened for genetic instability at microsatellite marker loci BAT-25, BAT-26, BAT-34C4, D2S123 and D17S250.Results MSI was detected in only five individuals from different families. Three tumours (4%) were unstable at more than two MSI loci and hence classified high-frequency MSI (MSI-H) according to a previous definition, Interestingly, two of the MSI-H tumours were from patients in families with both HPC and familial colon cancer.Conclusions Widespread MSI is a rare event in hereditary prostate cancer, indicating that defective DNA mismatch repair is not an important element in the genesis of HPC.