Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins
Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins
复制标题
明确的环状糖聚合物的合成及其物理性质及其与凝集素相互作用之间的关系
DOI：
10.1039/d2py00941b
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发表时间：
2022
影响因子：
4.6
通讯作者：
Miura Yoshiko
中科院分区：
文献类型：
--
作者：
Nagao Masanori;Hoshino Yu;Miura Yoshiko
环状聚合物具有不同于线性聚合物的拓扑结构，显示出作为新型纳米材料的潜力。在这篇文章中，我们报道了具有生物分子识别功能单元的定义明确的环状糖基共聚物的合成，并评估了它们的物理性质，包括分子流动性。环状糖基共聚物的分子流动性被抑制，削弱了它们与靶蛋白的相互作用，表明聚合物的拓扑结构对分子识别的影响。
Cyclic polymers, which have a different topology from that of linear polymers, show potential as novel nanomaterials. In this communication, we report the synthesis of well-defined cyclic glycopolymers that have functional units for biomolecular recognition and evaluated their physical properties including molecular mobility. The suppressed molecular mobility of the cyclic glycopolymers was found to weaken their interactions with target proteins, demonstrating the influence of polymer topology on molecular recognition.