5,7-DHT FACILITATED LORDOSIS - EFFECTS OF 5-HT AGONISTS
5,7-DHT FACILITATED LORDOSIS - EFFECTS OF 5-HT AGONISTS
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DOI：
10.1097/00001756-199206000-00024
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发表时间：
1992-06-01
期刊：
影响因子：
1.7
通讯作者：
FRANKFURT, M
中科院分区：
文献类型：
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作者：
AIELLOZALDIVAR, M;LUINE, V;FRANKFURT, M
通过联合外周给予5-HT激动剂8-OH-DPAT（8-羟基-2-[二-N-丙基氨基]四氢萘）或TFMPP（1-[间-三氟甲基苯基]哌嗪）和下丘脑内应用5-HT神经毒素5，7-DHT（5，7-二羟色胺），研究了5-HT（5-羟色胺）在调节脊柱前凸中的作用。5-HT 1A激动剂8-OH-DPAT显著抑制5，7-DHT处理和未处理大鼠的脊柱前凸。TFMPP是一种5-HT 1B和5-HT 1C受体激动剂，可显著促进5，7-DHT处理和未处理大鼠的脊柱前凸。我们的研究结果表明，下丘脑5-HT对脊柱前凸的抑制和促进作用都是通过突触后受体来调节的。
THE role of 5-HT (serotonin) in regulating lordosis was investigated by combining peripheral administration of the 5-HT agonists 8-OH-DPAT (8-hydroxy-2-[di-N-propylamino]tetralin) or TFMPP (1-[m-trifluoromethylphenyl] piperazine), with intrahypothalamic application of the 5-HT neurotoxin 5,7-DHT (5,7-dihydroxytryptamine). The 5-HT1A agonist, 8-OH-DPAT, significantly inhibited lordosis in 5,7-DHT-treated and non-treated rats. TFMPP, an agonist at 5-HT1B and 5-HT1C receptors, significantly facilitated lordosis in 5,7-DHT-treated and non-treated rats. Our results show that both inhibitory and facilitatory influences of hypothalamic 5-HT on lordosis, are modulated via postsynaptic receptors.