Enhanced measurement of CsI cluster ions for mass calibration in MALDI-MS using sugar alcohols
Enhanced measurement of CsI cluster ions for mass calibration in MALDI-MS using sugar alcohols
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DOI：
10.1039/c4ay02509a
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Mochizuki, Shunsuke
中科院分区：
文献类型：
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作者：
Mochizuki, Shunsuke
建立了一种用基质辅助激光解吸电离质谱仪(MALDI-MS)测定CsI_3中CsI团簇离子((CsI)(N)Cs+和(CsI)(N)I-)的简便方法。在MALDI板上将CsI3与添加剂糖醇(例如甘油)或糖(例如二羟丙酮)一起应用，在线性模式下得到质量范围超过m/z 10000的足够系列的CSI团簇离子。这些添加剂可能与改善CsI3在MALDI板上的分布有关，从而有助于团簇离子的有效测量。由于易于操作，CsI3和糖醇或糖溶液构成了适合于MALDI-MS仪器的通用质量校准剂。
A simple method for measuring CsI cluster ions ((CsI)(n)Cs+ and (CsI)(n)I-) from CsI3 for mass calibration was developed using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The application of CsI3 with an additive, sugar alcohol (e.g., glycerol) or saccharide (e.g., dihydroxyacetone), on the MALDI plate resulted in an adequate series of CsI cluster ions within a mass range extending to over m/z 10 000 in the linear mode. The additives may be involved in improving the distribution of CsI3 on the MALDI plate, thus aiding the effective measurement of cluster ions. Because of their ease in handling, CsI3 and sugar alcohol or saccharide solutions comprised a suitable general-purpose mass calibrant for MALDI-MS instruments.